益肾清利活血法治疗特发性膜性肾病的临床研究

发布时间：2018-05-11 13:18

本文选题：特发性膜性肾病 + 益肾清利活血法　；参考：《南京中医药大学》2017年硕士论文

【摘要】：目的:观察益肾清利活血法对于特发性膜性肾病患者的治疗效果,从中医理论探讨该治疗方法的可行性,分析总结该治法的特点。方法:本研究分为两个部分。理论研究为收集古今中外文献以分别阐述西医与中医对于特发性膜性肾病的认识。临床研究收集特发性膜性肾病患者40例,在西医基础治疗同时以益肾清利活血法治疗6个月,通过自身对照的方法,观察治疗前后患者相关指标的变化,做出统计分析,并阐述孙伟教授以该法治疗特发性膜性肾病的经验。结果:1.症状疗效:经6个月治疗,38名患者临床症状积分较治疗前下降,差值有统计学意义(P＜0.05),该治法症状疗效总有效率为82.5%;患者腰脊酸痛、疲倦乏力、浮肿、少气懒言、手足心热、肢体困重等主要症状均获得显著改善(P0.05)。2.临床疗效:40例患者经治疗后完全缓解的有6名(15%),部分缓解的病例共28例(70%),未缓解6例(15%),总体有效率为85%。患者UTP、D-D、TC及TG均经治疗后下降,前三者有统计学意义(P＜0.05)。6个月后患者Alb显著提升(P＜0.05),Scr稳定在正常范围,差异无统计学意义(P0.05)。3.安全性指标:治疗过程中未出现明显不良事件,安全性指标(K+、ALT、AST、Hb)于正常范围内稳定,差异无统计学意义(P0.05)。结论:研究显示益肾清利活血法可显著改善患者的临床症状,并可在6个月疗程内达到降低尿蛋白、调脂抗凝、提升血浆白蛋白、稳定肾功能等效果,且该治法具有安全可行性。
[Abstract]:Objective: to observe the therapeutic effect of Yishen Qingli Huoxue method on idiopathic membranous nephropathy and discuss the feasibility of this method from the theory of traditional Chinese medicine. Methods: this study was divided into two parts. The theoretical study is to collect the literature of ancient and modern countries to explain the understanding of idiopathic membranous nephropathy between western medicine and traditional Chinese medicine. In the clinical study, 40 patients with idiopathic membranous nephropathy were treated with Yishen Qingli Huoxue method at the same time in western medicine for 6 months. Through self-control method, the changes of related indexes before and after treatment were observed and statistical analysis was made. Professor Sun Wei's experience in treating idiopathic membranous nephropathy with this method was described. The result is 1: 1. Symptom efficacy: after 6 months of treatment, the clinical symptom score of 38 patients was lower than that before treatment, the difference was statistically significant (P < 0.05), the total effective rate of the treatment was 82.5. The main symptoms such as limb weight were significantly improved (P0.05. 2). There were 6 patients with complete remission after treatment, 28 patients with partial remission, and 6 patients without remission. The overall effective rate was 85. The levels of TC and TG in patients with UTP D-DN decreased after treatment, and the first three were significantly decreased (P < 0.05). After 6 months, the Alb of the patients increased significantly (P < 0.05) and the SCR was stable in the normal range (P < 0.05), and there was no significant difference (P < 0.05). Safety index: there were no obvious adverse events in the course of treatment, and the safety index was stable in normal range (P 0.05). Conclusion: the study shows that Yishen Qingli Huoxue method can significantly improve the clinical symptoms of patients, and can reduce urinary protein, regulate lipid and anticoagulation, improve plasma albumin, stabilize renal function, and so on. The method is safe and feasible.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.5

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