自拟白术散治疗新生儿抗生素相关性腹泻（脾虚证）的临床观察

发布时间：2018-05-14 12:46

本文选题：新生儿 + 抗生素相关性腹泻　；参考：《湖南中医药大学》2016年硕士论文

【摘要】：目的观察自拟白术散治疗新生儿抗生素相关性腹泻(脾虚证)的临床疗效,为其临床运用提供理论实践依据。方法采用随机、单盲、对照的方法,将60例新生儿抗生素相关性腹泻(脾虚证)的患儿随机分为自拟白术散治疗组30例和西药对照组30例,连续3天为一个疗程,根据腹泻改善情况连续观察1-2个疗程,比较治疗前和用药3天后两组患儿临床疾病疗效、脾虚证症状积分的变化,比较2组腹泻治愈天数,安全性指标变化情况并观察用药中有无不良反应,探讨自拟白术散在临床运用的优势。结果(1)治疗组与对照组腹泻持续时间的比较:治疗组腹泻持续时间为3.900±1.269天,对照组腹泻持续时间4.800±1.215天,差异明显,有统计学意义。(2)治疗组与对照组两组之间治疗疗效的比较:治疗组30例中临床痊愈9例,显效11例,有效10例,无效0例,总有效率100%。对照组30例其中临床痊愈5例,显效6例,有效16例,无效3例,总有效率90%。治疗组较对照组疗效好(Z=-2.352,P=0.0190.05)有统计学意义。(3)治疗后两组脾虚证症状积分均有下降,治疗组下降的幅度更大。结论自拟白术散佐治新生儿AAD(脾虚证)起效快,疗效更好,对患儿症状和体征的改善优于对照组,且无明显副作用。
[Abstract]:Objective to observe the clinical effect of self-made Atractylodes powder in the treatment of neonatal antibiotic-associated diarrhea (spleen deficiency syndrome) and to provide theoretical and practical basis for its clinical application. Methods 60 newborns with antibiotic associated diarrhea (spleen deficiency syndrome) were randomly divided into two groups: the treatment group (n = 30) and the control group (n = 30). According to the improvement of diarrhea, 1-2 courses of treatment were observed continuously, the curative effect of clinical diseases and the symptom score of spleen deficiency syndrome were compared between the two groups before treatment and 3 days after treatment, and the days of cure of diarrhea were compared between the two groups. The changes of safety indexes and the adverse reactions were observed, and the advantages of self-made Atractylodes macrocephala powder in clinical application were discussed. Results 1) the duration of diarrhea was 3.900 卤1.269 days in the treatment group and 4.800 卤1.215 days in the control group. Comparison of the therapeutic effects between the treatment group and the control group: in the treatment group, 9 cases were clinically cured, 11 cases were markedly effective, 10 cases were effective, 0 cases were ineffective, and the total effective rate was 100%. In the control group, 5 cases were clinically cured, 6 cases were markedly effective, 16 cases were effective, 3 cases were ineffective, and the total effective rate was 90 cases. The curative effect of the treatment group was better than that of the control group. There was a significant difference between the treatment group and the control group (0.0190.05).) after treatment, the symptom scores of spleen deficiency in the two groups were all decreased, and the amplitude of the decrease in the treatment group was even greater than that in the control group. Conclusion the treatment of AAD (spleen deficiency syndrome) by self-made Atractylosam powder is more effective and better than that of the control group, and there is no obvious side effect in the treatment of AAD (spleen deficiency Syndrome) in the control group.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R272

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