复方芎芍胶囊治疗糖尿病周围神经病变作用机制的研究进展

发布时间：2018-05-15 07:34

本文选题：糖尿病周围神经病变 + 复方芎芍胶囊　；参考：《中国药房》2017年14期

【摘要】：目的:探讨复方芎芍胶囊对糖尿病周围神经病变(DPN)可能的作用机制。方法:查阅近年来国内外相关文献,就DPN的发病机制和复方芎芍胶囊中主要组分对DPN可能的作用机制进行归纳和总结。结果:DPN发病机制与氧化应激、神经发生促炎性变化等密切相关。复方芎芍胶囊治疗DPN可能涉及多重机制,川芎、赤芍通过调控超氧化物歧化酶(SOD)水平、一氧化氮合酶(NOS)蛋白活性表达,清除氧自由基,抑制氧化应激;黄精、地骨皮和海藻等调节血糖,抑制微血管功能障碍导致的神经功能受损与退化,主要机制可能与降低血清一氧化氮(NO)和NOS水平相关;桑枝通过影响丝裂原活化蛋白激酶(MAPK)/细胞外调节蛋白激酶(ERK)信号途径p-ERK的蛋白表达,抑制诱导型NOS(i NOS)、环氧化酶(COX)-2等靶基因及蛋白表达发挥抗炎作用。结论:复方芎芍胶囊主要通过抑制机体氧化应激治疗DPN,其他作用机制还包括控制血糖和抗炎,具体作用靶点与调控SOD水平、NOS活性以及MAPK信号通路密切相关。
[Abstract]:Objective: to explore the possible mechanism of compound Xiongshao capsule on diabetic peripheral neuropathy (DPN). Methods: the pathogenesis of DPN and the possible action mechanism of the main components of compound Xiongshao capsule on DPN were summarized and summarized by referring to the relevant literatures at home and abroad in recent years. Results the pathogenesis of DPN was closely related to oxidative stress and inflammatory changes of nerve. Compound Xiongshao capsule may involve multiple mechanisms in the treatment of DPN. Ligusticum Chuanxiong and Radix Paeoniae Paeoniae Alba can scavenge oxygen free radicals and inhibit oxidative stress by regulating the level of superoxide dismutase (SOD), nitric oxide synthase (NOS) protein, and inhibiting oxidative stress. The main mechanism may be related to the reduction of serum nitric oxide (no) and NOS levels. Mulberry branch inhibits the expression of target genes and proteins such as inducible NOS(i NOSN and cyclooxygenase COX-2 by affecting the expression of mitogen-activated protein kinase (MAPK) / extracellular regulated protein kinase (ERK) signal pathway p-ERK. Conclusion: Fufang Xiongshao capsule can be used to treat SOD by inhibiting oxidative stress. Other mechanisms include controlling blood glucose and anti-inflammation. The specific targets are closely related to the regulation of SOD activity and MAPK signaling pathway.
【作者单位】：上海交通大学医学院附属瑞金医院药剂科;
【基金】：上海市科研计划项目(No.12401903000) 上海市临床药学重点专科建设项目
【分类号】：R277.7

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