宣痹通脉颗粒治疗稳定型心绞痛痰瘀互结证的临床研究及对SOD、胱抑素C的影响

发布时间：2018-05-16 05:04

本文选题：宣痹通脉颗粒 + 稳定型心绞痛　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:通过临床实验观察宣痹通脉颗粒治疗稳定型心绞痛痰瘀互结证的疗效和安全性,判断宣痹通脉颗粒的临床应用价值,并讨论其组方原理和作用机制。方法:按照稳定型心绞痛的中、西医诊断标准和病例纳入标准,从门诊及病房选取自愿参与研究的60例患者,按照随机分配的原则,分为治疗组和对照组,每组30例,治疗组与对照组都采用常规西药治疗,治疗组在常规西药治疗基础上加用宣痹通脉颗粒,治疗1个月后,观察两组临床症状、证候、心电图、硝酸甘油的使用量及实验室检查指标的变化,并对症状及证候进行量化评分,作出疗效评价,并做统计学分析。结果:宣痹通脉颗粒对症状的缓解及证候的改善均有显著的疗效,并且治疗组的改善更加明显;在心电图的改善方面,治疗组的效果也优于对照组;同时在改善血脂、超氧化物歧化酶(SOD)、胱抑素C各项实验检测指标方面,治疗组效果更明显;治疗组患者硝酸甘油的服用量减少更加明显。临床观察过程中并未出现不良反应,所有安全性检测指标无异常变化。结论:宣痹通脉颗粒联合西药常规治疗可明显改善患者临床症状、体征,减少患者硝酸甘油的服用量,提高临床疗效,且能够有效预防冠心病的进一步进展。
[Abstract]:Objective: to observe the efficacy and safety of Xuanbi Tongmai granule in treating stable angina pectoris with phlegm and blood stasis syndrome through clinical experiment, to judge the clinical application value of Xuanbi Tongmai granule, and to discuss its principle and mechanism. Methods: according to the diagnostic criteria of stable angina pectoris, western medicine diagnostic criteria and case inclusion criteria, 60 patients who volunteered to participate in the study were selected from outpatients and wards. According to the principle of random distribution, they were divided into treatment group and control group with 30 cases in each group. Both the treatment group and the control group were treated with conventional western medicine. The treatment group was treated with Xuanbi Tongmai granule on the basis of routine western medicine. After one month of treatment, the clinical symptoms, syndromes and electrocardiogram were observed. The usage of nitroglycerin and the changes of laboratory examination indexes were evaluated by quantitative evaluation of symptoms and syndromes, and statistical analysis was made. Results: Xuanbi Tongmai granule had significant curative effect on symptom relief and syndrome improvement, and the improvement of treatment group was more obvious, the effect of treatment group was also better than that of control group in improving electrocardiogram, at the same time, the effect of treatment group was also better than that of control group. The effect of superoxide dismutase (SOD) and cystatin C was more obvious in the treatment group than in the treatment group, and the dosage of nitroglycerin decreased more obviously in the treatment group. There were no adverse reactions during clinical observation, and no abnormal changes were found in all safety indicators. Conclusion: Xuanbi Tongmai granule combined with western medicine can obviously improve the clinical symptoms and signs of patients, reduce the dosage of nitroglycerin, improve the clinical efficacy, and can effectively prevent the further progress of coronary heart disease.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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