谢晶日教授治疗功能性便秘的用药规律研究

发布时间：2018-05-18 01:28

本文选题：功能性便秘 + 用药规律　；参考：《黑龙江中医药大学》2016年硕士论文

【摘要】：目的：利用统计学软件对谢晶日教授治疗功能性便秘的中药进行分析,探讨谢晶日教授的组方用药规律,进而总结谢晶日教授治疗本病的用药经验。方法：收集2010年3月至2015年12月经谢晶日教授门诊诊治的功能性便秘患者病例。运用EXCEL、SPSS19.0统计软件,从药物、药类、四气、五味、归经方面,对处方用药进行频数分析、聚类分析,探讨谢晶日教授治疗功能性便秘的临床用药规律。结果：1.根据病例纳入标准与排除标准共筛选出符合病例164例,共涉及用药134味,使用2751次,频数在20次以上的药物共有28味,其累计使用频率达80.44%。枳实(145次)、槟榔(145次)、大黄(129次)、柴胡(125次)、厚朴(123次)、火麻仁(116次)、郁李仁(114次)、乌药(114次)、白豆蔻(111次)、草豆蔻(103次)依次是频数频率使用前10位的药物。2.药类涉及11类,理气药(26.44%)、化湿药(18.14%)、补虚药(14.53%)、泻下药(14.41%)、清热药(7.58%)、消食药(5.58%)、活血化瘀药(3.93%)占药类累计使用频率90.61%,依次是频数频率使用前7位的药类。3.温性(47.84%)、微寒性(18.42%)、平性(17.78%)依次是频数频率使用前3位的四气,辛味(37.64%)、苦味(26.63%)、甘味(23.90%)依次是频数频率使用前3位的五味,脾经(22.27%)、胃经(21.23%)、大肠经(14.26%)、肺经(13.19%)、肝经(9.15%)依次是频数频率使用前5位的药物归经。4.聚类分析得到常用药对组合8对,常用药物组合9组。结论：1.枳实、槟榔、大黄、柴胡、厚朴、火麻仁、郁李仁、乌药、白豆蔻、草豆蔻是谢师治疗功能性便秘的主要药物；2.药类中的理气药、化湿药、补虚药、泻下药、清热药、消食药、活血化瘀药,四气中的温性、微寒性、平性,五味中的辛味、甘味、苦味,归经中的脾经、胃经、大肠经、肺经、肝经是谢师治疗功能性便秘用药的主要药类、四气、五味、归经；3.气机不畅是功能性便秘的标病机,血瘀、湿阻、气血阴阳不足是本病机；脏腑辨证、八纲辨证、气血津液辨证是谢师常用的辨证分析方法；辨病、辨证相结合是谢师治疗功能性便秘的核心用药法则。
[Abstract]:Objective: to analyze the effect of Professor Xie Jingri on the treatment of functional constipation by using statistical software, and to explore the rule of prescription used by Professor Xie Jingri, and to sum up the experience of Professor Xie Jingri in the treatment of this disease. Methods: from March 2010 to December 2015, the patients with functional constipation were collected. By using statistical software excel SPSS 19.0, the frequency and cluster analysis of prescription drug use were carried out from the aspects of drugs, four qi, five flavors and meridians, and the clinical drug use law of Professor Xie Jingri in the treatment of functional constipation was discussed. The result is 1: 1. According to the criteria of inclusion and exclusion of cases, 164 cases were screened out, involving 134 kinds of drugs, 2751 times of use, 28 kinds of drugs with frequency more than 20 times, the cumulative frequency of use reached 80.44%. Fructus Aurantii 145 times, Areca capsicum 145 times, Rhubarb chinensis 129 times, Bupleurum chinensis 125 times, Magnolia officinalis 123 times, Flamella sinensis 116 times, Lilium rubrum 114 times, black medicine 114 times, cardamom 111 times, cardamom 103 times) are the drugs in the first 10 places of frequency. There are 11 kinds of drugs involved in this study. The cumulative use frequency of these drugs is 96.61, 18.14, 14.53, 14.41g, 7.58g, 5.58g, 3.93g, respectively, and is followed by the seven drugs in the first seven places in order of frequency. The temperature is 47.84m, the slightly cold is 18.42, the flat is 17.78), the frequency is the first three, the Xin Wei is 37.64, the bitter is 26.63 and the sweetness is 23.90) the top three are the first three. The spleen meridian was 22.27m, the stomach meridian was 21.23m, the large intestine meridian was 14.26m, the lung meridian was 13.19m, and the liver meridian was 9.15.The order of the medicine was. 4. Cluster analysis showed 8 pairs of common drug pairs and 9 groups of common drug combinations. Conclusion 1. Fructus Aurantii, Areca nut, rhubarb, Bupleurum, Magnolia officinalis, Ramie seed, Tui Li Ren, black medicine, white nutmeg and cardamom are the main drugs used by Xie Shi to treat functional constipation. The drugs of regulating qi, dehumidifying dampness, tonifying deficiency, catharsis, heat clearing medicine, disinfecting medicine, activating blood circulation and removing blood stasis, the warmth of the four qi, the slight cold, the flat nature, the symplectic flavor of the five flavors, the sweet taste, the bitter taste, the spleen meridian, the stomach meridian, the large intestine meridian in the return to the meridian, Lung Meridian, liver Meridian is Xie Shi treatment of functional constipation of the main drugs, four qi, five flavor, Gui Jing 3. Qi Qi unobstructed is the standard pathogenesis of functional constipation, blood stasis, dampness obstruction, deficiency of qi, blood yin and yang are the pathogenesis of the disease; the syndrome differentiation of zang-fu organs, eight principles and qi, blood and body fluid are commonly used by Xie Shi for syndrome differentiation and analysis; The combination of syndrome differentiation is the core medication principle of Xie Shi in the treatment of functional constipation.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R249;R256.35

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