参补汤治疗气虚血瘀型月经过多的临床研究

发布时间：2018-05-18 10:59

本文选题：参补汤 + 气虚血瘀型　；参考：《广西中医药大学》2017年硕士论文

【摘要】：目的:观察参补汤治疗气虚血瘀型月经过多的临床疗效。明确该方治疗气虚血瘀型月经过多的临床疗效,初步评价其临床有效性及安全性,以期为月经过多患者提供更可靠的治疗方法。方法:本研究遵循平行随机对照的临床研究方法,将符合纳入标准的气虚血瘀型月经过多患者随机分为治疗组(56例)和对照组(54例),脱落2例,实际完成治疗组(54例)、对照组(54例),分别于经期第3天口服参补汤(治疗组)和宫血停颗粒(对照组)进行治疗,连续5天,疗程为3个月经周期。观察并记录两组患者治疗前后月经及相关的中医临床症状评分、血红蛋白、子宫内膜厚度、血清雌二醇、血清孕酮变化及用药过程中有无不良反应,对观察结果进行统计分析。结果:两组治疗前、后自身对照,主要疗效观察指标:月经证候积分、全身证候积分、总证候积分相比,P0.01,差异显著,具有统计学意义;各检查指标:子宫内膜厚度、血清E2、P水平,P0.05,无统计学意义;血红蛋白(Hb)值,P0.05,具有统计学意义。两组治疗后组间对照,总疗效:治疗组总有效率为92.59%,对照组组总有效率为79.63%,P0.05,有统计学意义;主要疗效观察指标:月经证候中月经量、月经质、总证候积分相比,P0.05,具有统计学意义;全身证候积分相比,P0.05,无统计学意义,但小腹疼痛、口干不欲饮单个证候积分比较P0.05,具有统计学意义;各检查指标:子宫内膜厚度、血清E2、P水平,P0.05,无统计学意义;Hb值相比,P0.05,具有统计学意义。治疗组、对照组均未观察到不良反应。结论:参补汤对治疗气虚血瘀型月经过多患者临床疗效确切,能恢复月经量,较好的改善中医相关症状,显著降低中医证状积分,提高血红蛋白值,且未见明显副作用和不良反应,值得临床推广、应用。
[Abstract]:Objective: to observe the clinical effect of Shenbu decoction on menorrhagia of qi deficiency and blood stasis type. To evaluate the clinical efficacy and safety of the prescription in treating menstruation with qi deficiency and blood stasis, and to provide a more reliable treatment for the patients with menorrhagia. Methods: according to the clinical study method of parallel randomized control, the patients with menorrhagia of Qi deficiency and blood stasis type were randomly divided into treatment group (n = 56) and control group (n = 54). The treatment group (n = 54) and control group (n = 54) were treated with Shenbu decoction (treatment group) and Gongxuting granule (control group) respectively on the 3rd day of menstrual period for 5 days for 3 menstrual cycles. The clinical symptoms of menstruation, hemoglobin, endometrial thickness, serum estradiol, serum progesterone and adverse reactions were observed and recorded before and after treatment. Results: before and after treatment, the main outcome measures: menstrual syndrome integral, systemic syndrome integral, total syndrome score, compared with P0.01, the difference was significant, with statistical significance. There was no significant difference in serum E _ 2P level (P _ (0.05) and hemoglobin (HB) value (P _ (0.05). The total effective rate of the treatment group was 92.599.The total effective rate of the control group was 79.63g / kg P 0.05, which was statistically significant; main outcome measures: menstrual syndrome, menstrual quality, menstrual quality, Compared with P0.05, the score of total syndromes was statistically significant, the score of systemic syndrome was not statistically significant compared with that of P0.05, but the scores of abdominal pain and dry mouth were statistically significant compared with P0.05. The serum E _ 2 P level and P _ (0.05) had no statistical significance compared with that of P _ (0.05), and there was no significant difference between P _ (0.05) and P _ (0.05). No adverse reactions were observed in the treatment group and the control group. Conclusion: Shenbu decoction is effective in treating excessive menstruation of qi deficiency and blood stasis type, can recover menstrual volume, improve TCM symptoms, decrease syndromes of TCM, and increase hemoglobin value. There were no obvious side effects and adverse reactions, so it was worth popularizing and applying.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.111

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