肝豆汤联合二巯基丙磺酸钠对湿热内蕴型肝豆状核变性患者的影响

发布时间：2018-05-18 18:25

本文选题：肝豆状核变性 + 肝豆汤　；参考：《中国实验方剂学杂志》2017年17期

【摘要】：目的:探讨肝豆汤联合二巯基丙磺酸钠治疗对湿热内蕴型肝豆状核变性患者的安全性及疗效性的影响。方法:回顾性分析湿热内蕴型肝豆状核变性患者245例,其中治疗组125例,对照组120例,治疗组为中药肝豆汤联合二巯基丙磺酸钠治疗,对照组选择单独应用二巯基丙磺酸钠治疗;在治疗前、治疗后分别进行globleassessment scale(GAS)评分,并观察24 h尿铜、肝功能、肾功能、白细胞、血小板等指标。结果:两组患者在治疗后,GAS评分均明显下降,其中以治疗组改善明显(P0.05);两组患者肝功能均得到明显改善,其中治疗组改善明显(P0.05),治疗后治疗组驱铜效果明显优于对照组(P0.05)。治疗4个疗程后对照组出现明显白细胞减少,治疗组无变化,两组患者具有明显差异(P0.05)。治疗后治疗组出现20例不良反应,对照组42例,主要为神经系统损害、白细胞减少、胃肠道反应、肝功能损害等,两组患者比较差异明显(P0.05)。结论:肝豆汤联合二巯基丙磺酸钠治疗肝豆状核变性具有明显的改善神经功能、改善肝功能、提高驱铜疗效作用,并可有效防止单独西药驱铜治疗引起的白细胞减少,安全有效。
[Abstract]:Objective: to investigate the effect of Gandou decoction combined with sodium dimercaptopropanesulfonate on the safety and efficacy of damp-heat endogenous hepatolenticular degeneration. Methods: a retrospective analysis of 245 cases of damp-heat endogenous hepatolenticular degeneration, 125 cases in the treatment group, 120 cases in the control group, the treatment group was treated with Gandou decoction combined with sodium dimercapto propanesulfonate. The control group was treated with sodium dimercaptopropanesulfonate alone. Before and after treatment, globleassessment scalegel score was used, and 24 h urine copper, liver function, renal function, white blood cell, platelet and other indexes were observed. Results: after treatment, the scores of gas were significantly decreased in both groups, especially in the treatment group, the liver function of the two groups was improved obviously, among them, the treatment group was obviously improved by P0.05, and the treatment group was superior to the control group in the effect of removing copper. After 4 courses of treatment, leukopenia appeared in the control group, but there was no change in the treatment group. There was a significant difference between the two groups (P 0.05). There were 20 cases of adverse reactions in the treatment group and 42 cases in the control group after treatment. The main causes were nervous system damage, leukopenia, gastrointestinal tract reaction, liver function damage, etc. The difference between the two groups was significant (P 0.05). Conclusion: Gangdou decoction combined with sodium dimercaptopropanesulfonate can obviously improve the nerve function, liver function and copper repellent effect, and can effectively prevent the leukopenia caused by the treatment of western medicine alone in the treatment of hepatolenticular degeneration. Safe and effective.
【作者单位】：安徽中医药大学第一附属医院;安徽中医药大学;
【基金】：国家自然科学基金项目(81102592) 安徽省高校省级自然科学研究项目(KJ2013Z170)
【分类号】：R277.7

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