升阳益胃汤加减治疗腹泻型肠易激综合征（肝郁脾虚证）的临床观察

发布时间：2018-05-19 10:24

本文选题：腹泻型肠易激综合征 + 肝郁脾虚证　；参考：《成都中医药大学》2016年硕士论文

【摘要】：目的：通过升阳益胃汤加减治疗腹泻型肠易激综合征(肝郁脾虚证)的临床试验,观察其临床疗效、安全性及近期复发率,并探讨升阳益胃汤及风药在腹泻型肠易激综合征中的作用机理及应用。方法：将成都中医药大学附属医院消化科及老年病科门诊收集的符合腹泻型肠易激综合征(肝郁脾虚证)患者60例,随机分为治疗组和对照组,每组各30例。治疗组以升阳益胃汤加减治疗；对照组以匹维溴铵片联合蒙脱石散治疗。两组疗程均为4周。停药后比较两组治疗前后的总有效率、证候总积分、各项临床症状改善情况和两组药物的不良反应及三大常规、肝肾功、心电图的变化。对有效病例随访3个月,观察两组患者复发率。使用SPSS19.0统计软件对所得数据进行处理分析。结果：(1)治疗组总有效率为93.33%,优于对照组的56.67%,治疗组与对照组的总有效率比较其差异有统计学意义(p0.05)；(2)治疗组与对照组在各项临床症状改善程度比较中,治疗组优于对照组,差异有统计学意义(p0.05)；(3)治疗组与对照组均未见不良反应；(4)对有效病例随访3个月,治疗组复发率为17.86%,明显低于对照组的52.94%。二者比较差异有统计学意义(p0.05)；结论：升阳益胃汤治疗腹泻型肠易激综合征(肝郁脾虚证)疗效显著,患者各症状改善明显,优于对照组,且近期复发率较低,未见不良反应,值得临床推广应用。
[Abstract]:Objective: to observe the clinical effect, safety and recrudescence rate of Shenyang Yiwei decoction in treating diarrhea type irritable bowel syndrome (liver stagnation and spleen deficiency syndrome). To explore the mechanism and application of Shengyang Yiwei decoction and wind medicine in diarrhea irritable bowel syndrome. Methods: sixty cases of diarrhea irritable bowel syndrome (liver-stagnation and spleen deficiency syndrome) were randomly divided into treatment group and control group with 30 cases in each group. The treatment group was treated with Shengyang Yiwei decoction and the control group was treated with pivemine bromide tablets and montmorillonite powder. The course of treatment was 4 weeks in both groups. The total effective rate, syndromes score, the improvement of clinical symptoms and adverse drug reactions and the changes of liver and kidney function and electrocardiogram were compared between the two groups after the treatment. Effective cases were followed up for 3 months to observe the recurrence rate of the two groups. Use SPSS19.0 statistical software to process and analyze the data. Results the total effective rate of the treatment group was 93.33, which was better than that of the control group, and the total effective rate of the treatment group was better than that of the control group. There was a significant difference in the total effective rate between the treatment group and the control group. In the comparison of the improvement degree of clinical symptoms between the treatment group and the control group, the treatment group was better than the control group. The difference was statistically significant (P 0.05) there were no adverse reactions in the treatment group and the control group (P < 0.05). The recurrence rate in the treatment group was 17.86, which was significantly lower than that in the control group (52.94g). Conclusion: the therapeutic effect of Shengyang Yiwei decoction on diarrhea type irritable bowel syndrome (liver depression and spleen deficiency syndrome) is significant, the symptoms of the patients are obviously improved, better than the control group, and the recrudescence rate is low in the near future, and no adverse reactions are found. It is worth popularizing and applying in clinic.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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