伤科消肿汤治疗胫腓骨骨折术后肢体肿胀的临床研究

发布时间：2018-05-19 13:08

本文选题：胫骨骨折 + 腓骨　；参考：《浙江中医药大学》2017年硕士论文

【摘要】：目的观察伤科消肿汤治疗胫腓骨骨折术后肢体肿胀的临床疗效。方法将山东临沂市人民医院2015年7月～2016年12月收治的132例胫腓骨骨折患者纳入研究,随机分为实验1组(伤科消肿汤联合甘露醇治疗)、实验2组(单纯伤科消肿汤治疗)和对照组(单纯甘露醇治疗),每组44例。分别于术后第1天、第3天、第5天、第7天测量患侧小腿周径并比较3组患者的肿胀值(患侧小腿周径—健侧小腿周径),并于术后第7天参照《中药新药临床研究指导原则》标准评价疗效。结果3组患者肿胀值治疗过程中不同时间点间的比较,差异有统计学意义,存在时间效应,治疗后肿胀值均逐渐减小(F=3154.562,P=0.000);3组患者肿胀值总体上比较,组间差异有统计学意义,存在分组效应(F=5.057,P=0.008),两两比较,实验1组肿胀值减少优于实验2组,差异有统计学意义(P=0.0070.0125);实验1组肿胀值减少优于对照组,差异有统计学意义(P=0.0060.0125);实验2组肿胀值和对照组相比,组间差异无统计学意义(P=0.9740.0125);时间因素和分组因素存在交互效应(F=33.757,P=0.000)。术后第7天,实验1组的临床疗效优于实验2组和对照组,组间差异有统计学意义(Z=-3.772,P=0.000;Z=-5.136,P=0.000);实验2组和对照组相比,组间差异无统计学意义(Z=-1.533,P=0.125)。结论伤科消肿汤治疗胫腓骨骨折术后肢体肿胀疗效确切,且和甘露醇联合应用,效果更佳,值得临床推广应用。
[Abstract]:Objective to observe the clinical effect of Shangke Xiaozhong decoction on limb swelling after tibia and fibula fracture. Methods 132 patients with tibia and fibula fractures treated in Shandong Linyi people's Hospital from July 2015 to December 2016 were included in the study. The rats were randomly divided into experimental group (Shangke Xiaozong decoction combined with mannitol), experimental group 2 (simple treatment of Shangke Xiaozong decoction) and control group (simple mannitol treatment), with 44 cases in each group. On day 1, day 3, day 5, respectively, On the 7th day, the peripheral diameter of the affected leg was measured and the swelling values of the three groups were compared. The therapeutic effect was evaluated according to the guideline of clinical research of new Chinese medicine on the 7th day after operation. Results there were significant differences in the swelling values between the three groups in the course of treatment, and there was a time effect. After treatment, the swelling values of the three groups were gradually reduced. The swelling values of the three groups were compared with each other in general, and the differences between the three groups were statistically significant. The swelling value of group 1 was significantly lower than that of group 2 (P 0.0070.0125), and the swelling value of group 1 was better than that of control group (P 0.0060.0125), and the swelling value of group 2 was higher than that of control group (P < 0.05). There was no significant difference between the two groups (P < 0. 9740. 0125), but there was interaction between time factors and group factors (P < 0. 000). On the 7th day after operation, the clinical efficacy of experimental group 1 was better than that of experimental group 2 and control group, and the difference between the two groups was statistically significant (P < 0.05), but there was no significant difference between experimental group 2 and control group (P 0.125). Conclusion Shangke Xiaozong decoction is effective in treating limb swelling after tibia and fibula fracture, and it is better in combination with mannitol. It is worth popularizing in clinic.
【学位授予单位】：浙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R274.9

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