清肺润燥汤治疗感染后咳嗽（风燥伤肺型）的临床观察及对血清TNF-α、IL-8的影响

发布时间：2018-05-20 02:26

本文选题：清肺润燥汤 + 风燥犯肺型　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:通过观察清肺润燥汤治疗感染后咳嗽(风燥伤肺型)患者的临床症状的变化,评价其临床疗效,为中医学治疗感染后咳嗽提供临床依据。方法:选择黑龙江中医药大学附属第一医院呼吸科门诊就诊的70例感染后咳嗽患者随机分为治疗组(35例)和对照组(35例),治疗组予清肺润燥汤剂治疗,对照组予阿斯美(复方甲氧那明胶囊)治疗,观察疗程均为7天,在治疗后第3天和第7天比较两组患者治疗前后中医证候疗效及咳嗽频度、咳嗽强度、咳痰、咽痒、口干、鼻燥等症状的改善情况,并在治疗后7天进行疗效判定,比较和观察清肺润燥汤治疗前后的血清TNF-α水平及血清IL-8水平,客观评价清肺润燥汤对治疗感染后咳嗽(风燥伤肺型)的临床疗效。结果:1、临床疗效方面:治疗组总有效率为85.2%,对照组总有效率为81.2%,无统计学意义(P0.05),说明治疗组在临床疗效方面与对照组疗效相当。2、主症的比较:治疗后患者的主要症状咳嗽频度、咳嗽强度差异无统计学意义(P0.05),说明清肺润燥汤在主症咳嗽的改善情况与西药对照组疗效相当,咳痰积分有明显减轻,差异有统计学意义(P0.05)。3、次症的比较:对比治疗后患者各次症积分,其中咽痒积分无统计学意义(P0.05),口干积分有统计学意义(P0.05),鼻燥积分无统计学意义(P0.05)。4、治疗7天,治疗组痊愈4例,显效12例,有效12例,无效5例,总有效率85.2%。对照组痊愈2例,显效3例,有效21例,无效6例,总有效率81.2%。经统计学分析,其差异具无统计学意义(P0.05)。5、治疗7天后,治疗组的血清TNF-α水平低于治疗前,具有统计学意义(P0.05),治疗组的血清IL-8的水平治疗7天后低于治疗前,具有统计学意义(P0.05)。结论:清肺润燥汤能明显改善风燥犯肺型感染后咳嗽患者治疗前后的咳嗽、咳痰及口干积分,明显提高患者的生活质量,降低患者血清中肿瘤坏死因子-α及血清白介素-8的水平。患者在治疗期间无明显不良反应,是安全有效方法。
[Abstract]:Objective: to evaluate the clinical effect of Qingfei Runzao decoction (QFRD) in treating cough after infection (wind dryness and lung injury), and to provide clinical basis for the treatment of cough after infection in traditional Chinese medicine (TCM). Methods: seventy patients with cough after infection were randomly divided into treatment group (n = 35) and control group (n = 35). The treatment group was treated with Qingfei Runzao decoction. The control group was treated with Asmine (compound methoxifen capsule) for 7 days. On the 3rd and 7th day after treatment, the curative effect of TCM syndromes and cough frequency, cough intensity, expectoration, pharynx itch and dry mouth were compared between the two groups before and after treatment. The improvement of nasal dryness and other symptoms was evaluated 7 days after treatment. The levels of serum TNF- 伪 and serum IL-8 were compared and observed before and after treatment with Qingfei Runzao decoction. Objective to evaluate the clinical effect of Qingfei Runzao decoction on cough after infection (wind dryness injury lung type). Results: the total effective rate of the treatment group was 85.2 and the total effective rate of the control group was 81.2. There was no significant difference between the treatment group and the control group (P 0.05), which indicated that the curative effect of the treatment group was equal to that of the control group. The comparison of the main symptoms and cough frequency after treatment showed that the treatment group had the same curative effect as the control group. The difference of cough intensity was not statistically significant (P 0.05), which indicated that Qingfei Runzao decoction had the same curative effect as the western medicine control group, and the score of expectoration was obviously alleviated. The difference was statistically significant (P 0.05). 3. Comparison of symptoms: there were no significant differences in the scores of pharynx itching, dry mouth, nasal dryness and nasal dryness. After 7 days of treatment, 4 cases were cured in the treatment group, and there was no significant difference in the scores of pharynx itch and dry mouth (P 0.05), and there was no significant difference in the score of nasal dryness for 7 days after treatment, 4 cases in the treatment group were cured. The total effective rate was 85.2%. In the control group, 2 cases were cured, 3 cases were markedly effective, 21 cases were effective and 6 cases were ineffective. The total effective rate was 81.2%. After 7 days of treatment, the serum level of TNF- 伪 in the treatment group was lower than that before treatment and had statistical significance (P 0.05). The level of serum IL-8 in the treatment group was lower than that before treatment 7 days after treatment, and had statistical significance. Conclusion: Qingfei Runzao decoction can obviously improve the score of cough, expectoration and dry mouth before and after treatment, and improve the quality of life of the patients. The serum levels of TNF-伪 and IL-8 were decreased. There is no obvious adverse reaction during the treatment, so it is a safe and effective method.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R256.11

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