无比山药丸加减方治疗慢性尿路感染脾肾亏虚、湿浊潴留证的临床研究

发布时间：2018-05-20 20:42

本文选题：慢性尿路感染 + 无比山药丸加减方　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:观察无比山药丸加减方治疗慢性尿路感染脾肾亏虚,湿浊潴留证的临床疗效,评价无比山药丸加减方治疗慢性尿路感染的临床效果以及安全性,为丰富中医药治疗慢性尿路感染提供新的思路、减少抗生素的使用提供理论依据。方法:将符合纳入标准的60例患者,随机分为试验组30例,对照组30例。对照组予基础治疗加用复方石韦胶囊治疗,试验组在基础治疗的基础上予无比山药丸加减方中药煎剂。两组均治疗4周。观察患者治疗前后尿白细胞(WBC)、中段尿细菌培养及中医症状和证候积分的变化。所有数据处理均在SPSS17.0统计软件上进行,P0.05为有显著差异;P0.01为有非常显著差异;P0.05为无显著差异。结果:(1)中医证候疗效:试验组治愈率3.33%、显效率56.67%、有效率40.00%、总有效率100%,对照组显效率3.33%、有效率83.33%、无效率13.33%、总有效率86.67%。试验组用药前后症状积分相比具有非常显著的统计学差异(p0.01)。(2)理化指标:与对照组相比,试验组治疗后中医量化评分明显优于对照组(p0.01)、尿白细胞疗效效果优于对照组(p0.05)、中段尿细菌培养疗效效果优于对照组(p0.05)。(3)安全性:试验组治疗前后肝肾功能无显著改变(p0.05)且均在正常范围,临床应用安全,无明显副作用。结论:无比山药丸加减方治疗慢性尿路感染(劳淋)脾肾亏虚,湿浊潴留证,能显著改善患者尿频、尿急、遇劳即发、神疲乏力、腰膝酸软、头晕耳鸣等脾肾亏虚,湿浊潴留证的中医证候表现,能显著改善尿菌及临床症状,从而显示出无比山药丸加减方治疗本病的优势。
[Abstract]:Objective: to observe the clinical effect of Heishan pills plus and subtractive prescription in the treatment of chronic urinary tract infection with deficiency of spleen and kidney and retention of dampness, and to evaluate the clinical effect and safety of the treatment of chronic urinary tract infection. To enrich the treatment of chronic urinary tract infection with Chinese medicine to provide new ideas, reduce the use of antibiotics to provide a theoretical basis. Methods: 60 patients were randomly divided into trial group (n = 30) and control group (n = 30). The control group was treated with basic therapy plus compound Shiwei capsule, and the experimental group was treated with the decoction of Chinese medicine of the addition and subtractive prescription of Cengshan pills on the basis of basic treatment. Both groups were treated for 4 weeks. Before and after treatment, the changes of WBCU, bacterial culture in middle urine and TCM symptoms and syndromes were observed. All the data were processed on SPSS17.0 statistical software for significant difference (P0.05). P0.01 was very significant difference (P0.05) was no significant difference. Results: the curative effect of TCM syndromes: the cure rate of the experimental group was 3.33, the effective rate was 56.67, the effective rate was 40.00, the total effective rate was 100, the control group was 3.33, the effective rate was 83.33, the inefficiency was 13.33and the total effective rate was 86.67. There was a significant statistical difference in symptom scores before and after treatment in the trial group (P 0.01. 0. 2) physical and chemical indexes: compared with the control group, After treatment, the quantitative score of TCM in the experimental group was significantly better than that in the control group (p0.01g), the effect of urinary leukocyte was better than that of the control group (p0.05), and the effect of bacterial culture in the middle segment of urine was better than that of the control group (p0.05.) the safety of the experimental group was not significantly improved before and after treatment. And all in the normal range. The clinical application is safe and has no obvious side effects. Conclusion: the treatment of deficiency of spleen and kidney, retention of dampness and turbidity in patients with chronic urinary tract infection (Laolin) by adding and reducing prescription of Dingshan pills can significantly improve the frequency of urine, urination urgency, imminent fatigue, weakness of waist and knee, dizziness, tinnitus and other deficiency of spleen and kidney. The TCM syndromes of dampness retention syndrome can significantly improve the urine bacteria and clinical symptoms, thus showing the advantages of Heishanshan pills plus and minus prescription in the treatment of this disease.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5

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