健脾益肾活血泄浊法治疗CKD2-4期患者血脂异常的临床研究

发布时间：2018-05-21 08:24

本文选题：健脾益肾活血泄浊法 + CKD　；参考：《河南中医药大学》2016年硕士论文

【摘要】：目的:按照慢性肾脏病(CKD)一般常规治疗的前提下,本实验依据健脾益肾活血泄浊法对慢性肾脏病(CKD)2-4期患者血脂异常进行研究,通过治疗组及对照组的血脂水平、肾功能、中医症状积分的前后差异及变化趋势,更深一步地探讨此法对于血脂异常的影响。方法:实验中进行临床观察的60例患者均来自于河南中医药大学门诊或者住院病人,将此60例病人按照随机表分配为健脾益肾活血泄浊治疗组与血脂康胶囊组,每组30例患者,连续治疗12周,两个小组的基础治疗均采用常规方式,如降低血糖、控制血压、低蛋白含量的优质饮食如进食少量的牛奶、鸡蛋等。治疗组患者口服健脾益肾活血泄浊方,1剂/日(约400ml,早晚分两次服用);对照组患者口服血脂康胶囊(2粒/次,2次/天),在一观察周期内,将中医症状积分、血脂实验室指标(HDL、LDL、TC、TG)、肾功能(Scr、Bun)的前后变化进行比较和记录,系统观察这些指标变化与服用中药的关系。结果:1.治疗组与对照组均能降低血脂及肌酐、尿素氮水平,治疗组在降低TC、TG、Scr、Bun方面优于对照组(P0.05),在降低LDL-C和升高HDL-C方面与对照组相当(P0.05)。2.治疗组在改善中医临床症状方面(如腹胀、食少等),疗效优于对照组(P0.05)。结论:本实验初步证实了健脾益肾活血泄浊法对于慢性肾脏病(CKD)2-4期患者血脂异常的治疗是有效的,在改善患者肾功能、中医症状方面有一定疗效。
[Abstract]:Objective: according to the general routine treatment of chronic kidney disease (CKD), this experiment was based on the method of invigorating spleen, tonifying the kidney and activating blood circulation, to study the abnormal blood lipids in patients with chronic kidney disease at stage 2-4, and to study the level of blood lipid and renal function in the treatment group and control group. The difference and change trend of TCM symptom score, and the effect of this method on dyslipidemia were further discussed. Methods: all of the 60 cases of clinical observation were from outpatients or inpatients of Henan University of traditional Chinese Medicine. According to the random list, the patients were divided into two groups: the treatment group of invigorating spleen, tonifying kidney, activating blood circulation and discharging turbidity, and the group of Xuezhikang capsule, with 30 patients in each group. After 12 weeks of continuous treatment, both groups were treated in routine ways, such as lowering blood sugar, controlling blood pressure, and eating low-protein quality diets such as eating small amounts of milk and eggs. The patients in the treatment group were given one dose per day (about 400ml, twice in the morning and evening) of Jianpi Yishen Huoxue Xiezhuo decoction, while the control group patients were given 2 capsules of Xuezhikang capsule twice a time per day. In one observation period, the patients in the control group were integrated with the symptoms of traditional Chinese medicine. The changes of serum lipids in the laboratory were compared and recorded before and after HDL LDLT TGG and Scr-Bunn. The relationship between the changes of these indexes and the administration of traditional Chinese medicine was observed systematically. The result is 1: 1. The levels of serum lipids, creatinine and urea nitrogen in the treatment group and the control group were lower than those in the control group. The treatment group was superior to the control group in reducing TCG-TGG Scr-Bun, and in decreasing LDL-C and increasing HDL-C. The curative effect of the treatment group was better than that of the control group in improving the clinical symptoms of traditional Chinese medicine (such as abdominal distension, less food and so on). Conclusion: the method of invigorating spleen, tonifying kidney, activating blood circulation and discharging turbidity is effective in the treatment of chronic kidney disease (CKD) 2-4 patients with abnormal blood lipids. It is effective in improving the renal function of patients and in improving the symptoms of traditional Chinese medicine.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5

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