化滞柔肝颗粒对非酒精性脂肪性肝炎患者胰岛素抵抗的影响

发布时间：2018-05-22 14:38

本文选题：化滞柔肝颗粒 + 非酒精性脂肪性肝炎　；参考：《中成药》2017年08期

【摘要】：目的观察化滞柔肝颗粒(茵陈、决明子、大黄,等)对非酒精性脂肪性肝炎湿热蕴结证患者胰岛素抵抗的影响。方法将入选120例患者随机均分为两组,对照组[多烯磷脂酰胆碱胶囊(易善复)]和治疗组(化滞柔肝颗粒),两组均在控制饮食、加强有氧运动的基础上给予药物治疗。患者分别于治疗前后行身体质量指数、肝功能、血脂、血糖、胰岛素、脂联素和瘦素水平监测,稳态模式胰岛素抵抗指数计算及肝脏超声检查。结果治疗后,治疗组患者的血清谷丙转氨酶、谷草转氨酶、谷氨酰转肽酶、总胆固醇、甘油三酯、空腹血糖、空腹胰岛素水平及胰岛素抵抗指数均明显下降(P0.05),肝脂肪变程度有明显改善(P0.05),而血清脂联素水平明显升高(P0.05);与对照组比较,治疗组患者血清谷丙转氨酶、谷草转氨酶、谷氨酰转肽酶、总胆固醇、甘油三酯、空腹血糖、空腹胰岛素、脂联素水平、胰岛素抵抗指数与肝脂肪变程度的差异有统计学意义(P0.05)。此外两组患者治疗后身体质量指数、血清瘦素水平均有显著改善(P0.05);与对照组比较,治疗组患者身体质量指数、血清瘦素水平差异无统计学意义(P0.05)。结论化滞柔肝颗粒联合基础疗法通过降低胰岛素抵抗来有效改善湿热蕴结证的非酒精性脂肪性肝炎。
[Abstract]:Objective to observe the effect of Huazhi Rugan granule (Yinchen, Cassia seed, rhubarb, et al) on insulin resistance in patients with damp-heat accumulation syndrome of non-alcoholic fatty hepatitis. Methods 120 patients were randomly divided into two groups: the control group (Yi Shanfu) and the treatment group (Huazhi Rugan granule). Both groups were given drug therapy on the basis of controlling diet and strengthening aerobic exercise. Body mass index (BMI), liver function, blood lipid, blood glucose, insulin, adiponectin and leptin levels, steady-state model insulin resistance index and liver ultrasound were measured before and after treatment. Results after treatment, serum alanine aminotransferase, glutamyl transpeptidase, total cholesterol, triglyceride, fasting blood glucose were obtained in the treatment group. Fasting insulin level and insulin resistance index were significantly decreased (P 0.05), liver fatty degree was significantly improved (P 0.05), serum adiponectin level was significantly increased (P 0.05), and serum alanine aminotransferase (alt) and alanine aminotransferase (alt) were significantly increased in the treatment group compared with the control group. The levels of glutamyl transpeptidase, total cholesterol, triglyceride, fasting blood glucose, fasting insulin, adiponectin, insulin resistance index and the degree of hepatic adipogenesis were significantly different (P 0.05). In addition, the body mass index (BMI) and serum leptin level in the two groups were significantly improved after treatment, and there was no significant difference in BMI and leptin levels between the treatment group and the control group (P 0.05). Conclusion Huayiyugan granule combined with basic therapy can effectively improve non-alcoholic fatty hepatitis with damp-heat accumulation syndrome by reducing insulin resistance.
【作者单位】：湖北医药学院基础医学院生理学教研室;湖北医药学院附属人民医院中医科;
【分类号】：R259

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