针药联合治疗肿瘤患者化疗后消化道症状相关机制的临床研究

发布时间：2018-05-23 15:36

本文选题：平胃散 + 胃三针　；参考：《时珍国医国药》2017年01期

【摘要】：目的评价平胃散联合"胃三针"对肿瘤化疗后呕吐患者的止呕疗效及可能相关机制的探讨。方法将80例第三周期化疗后的肿瘤患者随机分为观察组和对照组各40例,其中观察组化疗后给予平胃散加减联合"胃三针"止呕,每日2次。对照组给予格拉司琼静滴止呕,每日2次,各服用1周时间观察两组患者治疗前后血清MTL及P物质的变化、以及治疗后第1、3、7天的呕吐症状分级及止呕疗效,及伴随症状的评估等。结果治疗后第1、3、7天对照组各级恶心呕吐减少例数均少于观察组,差异有统计学意义(P0.05)。两组患者治疗后较治疗前呕吐积分均明显减少,差异有统计学意义(P0.05);与对照组比较,观察组呕吐积分明显下降,差异具有统计学意义(P0.05)。观察组总有效率为94.28%,对照组治疗总有效率为81.81%,观察组疗效优于对照组,差异有统计学的意义(P0.05)。两组患者治疗后较治疗前,血清MTL水平明显升高,P物质明显下降,差异有统计学意义(P0.05),其中观察组升高MTL及降低P物质的的效果明显优于对照组,差异有统计学意义(P0.05)。结论平胃散加减联合"胃三针"可有效抑制肿瘤化疗后恶心呕吐等消化道症状,机制可能与提高了化疗后的血清MTL及降低了P物质相关。
[Abstract]:Objective to evaluate the antiemetic effect of Pingwei Powder combined with three Needles on patients with vomiting after chemotherapy. Methods 80 patients with cancer after the third cycle chemotherapy were randomly divided into two groups: the observation group (n = 40) and the control group (n = 40). In the control group, granisetron was given intravenous drip twice a day for one week to observe the changes of serum MTL and substance P before and after treatment, as well as the grade of vomiting symptom and the antiemetic effect on the 1st day and 3th day after treatment. And the evaluation of accompanying symptoms, etc. Results the number of cases of nausea and vomiting reduction in the control group was less than that in the observation group on the 7th day after treatment, and the difference was statistically significant (P 0.05). Compared with the control group, the vomiting score of the two groups decreased significantly after treatment, the difference was statistically significant (P 0.05), and that of the observation group was significantly lower than that of the control group (P 0.05). The total effective rate was 94.28 in the observation group and 81.81 in the control group. The curative effect of the observation group was better than that of the control group, and the difference was statistically significant (P 0.05). After treatment, the serum MTL level in the two groups was significantly higher than that before treatment, and the difference was statistically significant (P 0.05). The effect of increasing MTL and reducing substance P in the observation group was significantly better than that in the control group, and the difference was statistically significant (P 0.05). Conclusion addition and subtraction of Pingwei Powder combined with "three Needles" can effectively inhibit gastrointestinal symptoms such as nausea and vomiting after chemotherapy. The mechanism may be related to the increase of serum MTL and the decrease of substance P after chemotherapy.
【作者单位】：宁夏医科大学;宁夏医科大学总医院;
【基金】：宁夏回族自治区自然科学基金(No.NZ10159)
【分类号】：R273

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