自拟养血温经方治疗阴寒型雷诺氏病疗效观察

发布时间：2018-05-23 23:28

本文选题：养血温经 + 阴寒型　；参考：《华北理工大学》2016年硕士论文

【摘要】：目的通过观察养血温经方对阴寒型雷诺氏病患者的临床疗效,客观地评价自拟养血温经方治疗阴寒型雷诺氏病的临床疗效及安全性,为治疗本病找到新的思路方法,并及早推广使用。方法收集自2014年7月至2016年2月期间就诊患者,共计62例。所有研究对象年龄均在20~40岁,均符合中医诊断标准、西医诊断标准、纳入标准,且未在排除标准范围内。治疗组病例32例,给予口服自拟养血温经方治疗;对照组病例30例,给予口服复方夏天无片治疗。4周为一个疗程,2个疗程后统计结果。对两组总体的疗效、单项症状积分、红细胞变形指数、免疫系列及补体测定和握拳试验进行有效统计并随时记录结果。同时对一般体检项目做好登记,做出前后对比,对不良反应等现象的发生及处理方法做好详细记录,为本实验的安全性评价做好充分详细的准备。一般体检项目包括身高、体重、血、尿、便常规、肝肾功能、心电图。对以上进行综合分析后评定其疗效。结果1中医综合疗效比较:治疗组临床痊愈率为9.37%,显效率为53.12%,有效率为28.12%,总有效率为90.62%;对照组临床痊愈率为3.33%,显效率为23.33%,有效率为43.33%,总有效率为70%。2中医单项症状积分比较:两组积分较治疗前均有所降低。治疗组在“肢端颜色、冷感、肿胀感、麻木感、疼痛感”方面与对照组差异明显,“舌象、脉象”症状差异不显著。总体显示治疗组效果优于对照组。3红细胞变形指数比较:治疗后结果显示P=0.021,治疗组比对照组差异明显。4免疫系列及补体测定比较:用独立样本t检验显示,治疗后两组免疫系列及补体比较P0.05,差异明显,有统计学意义,治疗组效果优于对照组。5握拳试验比较:治疗后养血温经方组阳性反应人数较复方夏天无片组明显减少,对比效果明显。6安全性比较:两组一般体检项目前后变化不显著,在肝肾功能及血常规方面做出的具体数据统计分析后显示,P值均0.05,两组比较无统计学意义。7整体实验过程中未出现不良反应,用药安全可靠。结论1自拟养血温经方可有效减轻阴寒型雷诺氏病患者的痛苦,使患者临床症状减轻,控制发病率,值得在患者中推广应用。2自拟养血温经方这一中医药治疗方法在临床实验中,对肝肾功能及血常规指标变化无影响,疗效安全可靠。
[Abstract]:Objective to evaluate the clinical efficacy and safety of Yangxue Wenjing recipe (YXWJF) in the treatment of Yin-cold Raynaud's disease by observing the clinical effect of YXWJD on the patients with Yin-cold type Raynaud's disease, and to find a new way of thinking for the treatment of this disease. And early promotion of use. Methods 62 patients were collected from July 2014 to February 2016. All the subjects were 20 ~ 40 years old, which were in accordance with the diagnostic criteria of traditional Chinese medicine and western medicine, and were not included in the exclusion criteria. 32 cases in the treatment group were treated with self-made decoction of nourishing blood and wenjing, while 30 cases in the control group were treated with compound summer without tablets for 4 weeks as a course of treatment, and statistical results were obtained after 2 courses of treatment. The total curative effect, single symptom score, erythrocyte deformability index, immune series, complement determination and fist grip test in both groups were counted and recorded at any time. At the same time, the general physical examination items are registered, compared before and after, and the occurrence and treatment of adverse reactions are recorded in detail, so as to prepare the safety evaluation of this experiment in detail. General physical examination items include height, weight, blood, urine, stool routine, liver and kidney function, electrocardiogram. The curative effect was evaluated after comprehensive analysis. Results 1Compared with the comprehensive curative effect of TCM, the clinical cure rate of the treatment group was 9.377.The effective rate was 53.12, the effective rate was 28.12and the total effective rate was 90.62.The clinical cure rate of the control group was 3.33, the markedly effective rate was 23.33, the effective rate was 43.33, and the total effective rate was 70.2 single symptoms of TCM. Integral comparison: both groups had lower scores than before treatment. There were significant differences between the treatment group and the control group in terms of "extremity color, cold feeling, swelling feeling, numbness feeling, pain feeling", but there was no significant difference in the symptoms of "tongue image and pulse image" between the treatment group and the control group. The effect of the treatment group was better than that of the control group (P 0.021). The difference of immune series and complement in the treatment group was significantly higher than that in the control group. After treatment, the immune series and complement were significantly different between the two groups (P0.05). The effect of the treatment group was better than that of the control group (P 0.05). After treatment, the number of positive reaction in the Yangxue Wenjing prescription group was significantly lower than that in the compound summer without tablet group. Safety comparison: there was no significant change before and after the general physical examination in the two groups. The statistical analysis of the specific data of liver and kidney function and blood routine showed that the P value was 0.05. There was no significant difference between the two groups. 7. There was no adverse reaction in the whole experiment, and the medication was safe and reliable. Conclusion (1) Yangxue Wenjing prescription can effectively alleviate the pain of the patients with Yin-cold Raynaud's disease, reduce the clinical symptoms and control the incidence of disease. It is worth popularizing and applying the traditional Chinese medicine treatment method of self-made nourishing blood and wenching meridian prescription in the clinical experiment, which has no effect on the changes of liver and kidney function and blood routine index, and the curative effect is safe and reliable.
【学位授予单位】：华北理工大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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