补肾活血、化痰熄风法治疗帕金森病的临床研究
发布时间：2018-05-26 02:25
本文选题：帕金森病 + 加味五虎追风散 ； 参考：《广西中医药大学》2016年硕士论文
【摘要】：目的:探讨具有补肾活血、化痰熄风功效的加味五虎追风散治疗帕金森病的临床疗效。方法:将2014年5月至2015年10月在广西中医药大学第一附属医院老年病科和神经内科门诊及住院治疗的帕金森病患者110例随机分组,按1:1比例随机分配至对照组和治疗组,每组各55例,对照组予口服西药多巴丝肼片治疗,治疗组在对照组的基础上加用加味五虎追风散,两组均治疗3个月。治疗前后分别观察两组的中医证候量表评分、帕金森病统一评分量表(UPDRSⅡⅢ)、帕金森病改良Hoehn-Yahr分级、帕金森病生存质量量表(PDQ-39)、生活满意度(LSIB)评分、血清SOD、GSH-Px、MDA指标变化。结果:(1)两组治疗后中医证候评分比较,治疗组较对照组明显改善(P0.01);(2)UPDRSⅡⅢ评分组内比较:两组治疗后均较治疗前改善,差异有统计学意义(P0.05或P0.01);组间比较:治疗后治疗组在UPDRSⅡⅢ评分改善方面优于对照组,差异有统计学意义(P0.05);(3)两组Hoehn㤘Yahr分级治疗前后均无明显变化,差异均无统计学意义(P0.05);(4)两组治疗后PDQ-39评分比较,治疗组优于对照组(P0.05);(5)两组治疗后LSIB评分比较,治疗组明显优于对照组(P0.01);(6)两组治疗后血清SOD、GSH-Px活性比较,治疗组优于对照组(P0.01或P0.05);(7)两组治疗后血清MDA含量比较,治疗组明显优于对照组(P0.01)。结论:具有补肾活血、化痰熄风作用的加味五虎追风散可明显提高帕金森病的临床疗效,其作用机理可能与提高帕金森病患者血清SOD、GSH-Px的活性,将MDA控制在较低水平,使患者机体拥有更为理想的抗氧化能力有关。
[Abstract]:Objective: to explore the clinical effect of modified Wuhu Zafeng Powder (WHZF) on Parkinson's disease (PD) with the effect of tonifying kidney and activating blood circulation and eliminating phlegm and dispelling wind. Methods: from May 2014 to October 2015, 110 cases of Parkinson's disease were randomly divided into control group and treatment group, according to the proportion of 1:1, which were treated in Department of Geriatrics and Neurology, Department of Geriatrics and Neurology, first affiliated Hospital of Guangxi University of traditional Chinese Medicine. There were 55 cases in each group, the control group was treated by oral administration of dobutazid tablets, and the treatment group was treated with modified Wuhu zaifeng powder on the basis of the control group. The two groups were treated for 3 months. Before and after treatment, the scores of TCM syndromes scale, Parkinson's disease scale 鈪，
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