益气养阴活血法治疗慢性心力衰竭患者60例

发布时间：2018-05-26 05:44

本文选题：生脉散 + 佛手散　；参考：《环球中医药》2017年01期

【摘要】：目的探讨以生脉散合佛手散为基础方加减,采用益气养阴活血法治疗慢性心力衰竭(简称"心衰")的临床效果。方法选取本院2013年1月~2015年10月心内科住院或门诊接诊的慢性心衰患者120例作为研究对象。按随机数字表法分为联合治疗组和对照组,每组60例。对照组患者接受常规西医治疗;联合治疗组患者在西医治疗基础上,给予生脉散合佛手散加减治疗。测定和对比两组患者治疗前后左心室舒张末容积(left ventricular diastolic volume,LVEDV)、左室收缩末期容积(left ventricular end systolic volume,LVESV)、右室射血分数(right ventricular ejection fraction,RVEF)、小轴短缩率(fraction shorten,FS)、左室舒张早期E波的峰值流速(E值)和舒张晚期A波的峰值流速(A值),计算和比较两组患者E值/A值;测定和比较两组患者治疗前后血清促血管生成素-2(angiogenin-2,Ang-2)和内皮素-1(endothelin-1,ET-1)的表达;对比两组患者治疗后美国纽约心脏病学会(new york heart association,NYHA)心功能治疗有效率。结果两组患者治疗后各项检测值均较治疗前得到改善;治疗后,联合治疗组患者LVEDV值和LVESV值均高于对照组,联合治疗组患者EF和FS值均低于对照组,差异均具有统计学意义(P0.05);治疗后,联合治疗组E值显著高于对照组(P0.05),A值显著低于对照组(P0.05)。两组患者治疗前后A/E值差异无统计学意义(P0.05);治疗后,联合治疗组NYHA分级I级患者比例显著高于对照组患者,血浆Ang-2及ET-1水平显著低于对照组,差异具有统计学意义(P0.05)。结论在西医治疗基础上联合生脉散合佛手散加减治疗可显著降低慢性心衰患者的心衰程度,改善心脏功能,值得临床推广。
[Abstract]:Objective to study the clinical effect of supplementing qi and nourishing yin and activating blood circulation on chronic heart failure (CHF). Methods from January 2013 to October 2015, 120 patients with chronic heart failure were selected. According to the method of random digital table, 60 cases were divided into combined treatment group and control group. The patients in the control group were treated with routine western medicine and the patients in the combined treatment group were treated with Shengmaisan combined with Fohand Powder on the basis of western medicine treatment. Left ventricular diastolic volume LVEDVV, left ventricular end systolic volume LVEVV, right ventricular ejection fractionation RVEF, small axis shortening ratio and E value of early left ventricular diastolic wave were measured and compared between the two groups before and after treatment. ) and the peak flow velocity of late diastolic wave A were calculated and compared between the two groups. The expression of serum angiogenin-2 (Ang-2) and endothelin-1endothelin-1 (ET-1) before and after treatment were measured and compared between the two groups, and the effective rate of cardiac function was compared between the two groups. Results after treatment, the LVEDV and LVESV values in the combined treatment group were higher than those in the control group, and EF and FS values in the combined treatment group were lower than those in the control group. After treatment, the E value of the combined treatment group was significantly higher than that of the control group (P 0.05), and that of the control group was significantly lower than that of the control group (P 0.05). After treatment, the proportion of NYHA grade I patients in the combined treatment group was significantly higher than that in the control group, and the plasma Ang-2 and ET-1 levels were significantly lower than those in the control group (P 0.05). Conclusion on the basis of western medicine treatment, the combination of Shengmaisan and Fudousan can significantly reduce the degree of heart failure and improve heart function in patients with chronic heart failure, and it is worth popularizing in clinic.
【作者单位】：深圳市罗湖区罗湖医院集团罗湖中医院康复分院体检科;
【分类号】：R259

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