证候表型组学的理论问题与应用构想

发布时间：2018-05-27 03:32

本文选题：证候表型组学 + 动物模型　；参考：《中医杂志》2017年01期

【摘要】：动物行为分析是判定模型动物证候归属并理解中医证本质的核心关键技术。通过对现代动物行为学思路和方法进展的梳理与总结,提出证候/病证结合动物模型行为评价中的证候表型组学概念。通过分析这一学科领域中的若干关键理论问题,提出证候表型组学技术应用于中医药领域的若干构想,包括基因操纵技术的联合应用有望带来学科领域的大发展、长时程行为监控笼具是未来动物行为分析的可能趋势、对动物模型行为的结构分析有助于更好地理解证候表征的复杂内涵,为解决动物模型的证候属性判别、揭示中医证候的复杂内涵提供思路与方法。
[Abstract]:Animal behavior analysis is the key technology to identify the syndromes of model animals and understand the essence of TCM syndromes. By combing and summarizing the development of modern animal behavior, the syndromes phenotypic group concept of syndromes / syndromes combined with animal model behavior evaluation was put forward. Based on the analysis of some key theoretical problems in this field, this paper puts forward some ideas about the application of syndromes phenotypic techniques in the field of traditional Chinese medicine, including the application of gene manipulation technology, which is expected to bring about a great development in the subject field. Long-term behavior monitoring cage is the possible trend of animal behavior analysis in the future. The structural analysis of animal model behavior is helpful to better understand the complex connotation of syndromes, and to solve the problem of syndrome attribute discrimination of animal model. To reveal the complex connotation of TCM syndrome provides ideas and methods.
【作者单位】：山东中医药大学中医药经典理论教育部重点实验室;山东中医药大学脑行为分析实验室;南京中医药大学中医脑病研究重点实验室;北京中医药大学基础医学院;
【基金】：国家自然科学基金(81573854)
【分类号】：R228

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