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基于中医传承辅助系统治疗消化性溃疡的用药规律分析

发布时间:2018-05-27 10:25

  本文选题:消化性溃疡 + 中医传承辅助系统 ; 参考:《山东中医药大学》2016年硕士论文


【摘要】:目的:本研究拟通过对曹志群教授在临床工作中用于治疗消化性溃疡的相关方剂、中药进行整理归类,分析其内在用药规律,包括常用药物、药对、组方规律及用药指征,为临床辨证论治提供参考。方法:整理2010-2015年曹志群教授门诊病历资料,从中选择符合本次研究纳入标准病例127例,处方179首,应用“中医传承辅助系统”,采用该软件集成的规则分析、改进互信息法、复杂系统熵聚类及无监督的熵层次聚类等数据挖掘方法[1],对药物之间的规律进行相关性分析。结果:通过对179首处方进行分析,药物四气五味频次统计,以温性、寒性药和甘味、辛味、苦味最多见。使用频次大于36次的中药有25味,包括砂仁、黄芪、丹参、白术、清半夏、党参、醋元胡、蒲公英、炒枳壳、白芷、白芍、乌药、百合等。最常用的药物种类为补虚药,其次是理气药、清热药和活血化瘀药。基于关联规则分析,频次超过45次的药物组合共130组。基于复杂系统熵聚类方法,得出核心组合30个,基于无监督的熵层次聚类方法,演化出新处方15个。结论:通过对曹志群教授治疗消化性溃疡的处方进行分析,总结出以补益脾胃为主,辅以辛开苦降,调理脾胃气机,化湿消痰,并重视活血化瘀药的应用,配伍清热药以消胃中郁热的用药经验,临床效果显著,对临床治疗和指导用药具有相当大的推广价值。
[Abstract]:Objective: the purpose of this study was to sort out and classify the relevant prescriptions and traditional Chinese medicines used by Professor Cao Zhiqun in the treatment of peptic ulcer, and to analyze the internal drug use rules, including common drugs, drug pairs, prescription rules and indications of drug use. To provide reference for clinical treatment based on syndrome differentiation. Methods: from 2010 to 2015, Professor Cao Zhiqun's outpatient medical records were collected, 127 cases and 179 prescriptions were selected to meet the criteria of this study. The software was used to analyze the rules of integration and to improve the mutual information method. Data mining methods such as entropy clustering and unsupervised entropy hierarchical clustering in complex systems [1] were used to analyze the correlation between drugs. Results: according to the analysis of 179 prescriptions, the frequency of four factors and five flavors of drugs were analyzed. The most common drugs were warm, cold, sweet, pungent and bitter. More than 36 times of use of traditional Chinese medicine have 25 flavors, including Amomum, Astragalus, Salvia miltiorrhiza, Atractylodes macrocephala, Pinellia ternata, Codonopsis pilosula, vinegar Yuan Hu, dandelion, fried Fructus Aurantii, Angelica dahurica, Radix Paeoniae Alba, Radix The most commonly used drugs are tonifying and deficiency drugs, followed by Qi-regulating drugs, heat-clearing drugs and blood-activating drugs. Based on association rule analysis, there were 130 drug combinations with more than 45 times frequency. Based on the entropy clustering method of complex systems, 30 core combinations and 15 new prescriptions were obtained based on unsupervised entropy hierarchical clustering method. Conclusion: by analyzing the prescriptions of Professor Cao Zhiqun in the treatment of peptic ulcer, it is concluded that the main prescription is tonifying the spleen and stomach, supplementing the Xin Kaiyu, regulating the Qi of the spleen and stomach, removing dampness and eliminating phlegm, and paying attention to the application of promoting blood circulation and removing blood stasis. The clinical effect of the combination of antipyretic drugs for removing heat in the stomach is remarkable, and it is of great value in popularizing the clinical treatment and guiding the drug use.
【学位授予单位】:山东中医药大学
【学位级别】:硕士
【学位授予年份】:2016
【分类号】:R259

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