加味柴胡疏肝散治疗功能性消化不良（肝郁气滞证）临床疗效观察及其对胃电图的影响

发布时间：2018-05-27 11:13

本文选题：加味柴胡疏肝散 + 功能性消化不良　；参考：《湖南中医药大学》2016年硕士论文

【摘要】：目的:探讨加味柴胡疏肝散治疗功能性消化不良(肝郁气滞证)的临床疗效及其对胃电图的影响。方法:收集2015年2月至2016年1月湖南中医药大学第一附属医院脾胃病科门诊就诊符合纳入标准的FD肝郁气滞证患者130例,随机分为治疗组64例、对照组66例,治疗组服用加味柴胡疏肝散,对照组口服泮托拉唑肠溶胶囊及多潘立酮片剂,观察比较两组治疗后的临床疗效、中医证候积分变化及胃电DF、N%、PR的变化情况。结果:1.疾病疗效:治疗组总有效率92.19%,对照组总有效率80.30%,治疗组优于对照组,差异有统计学意义(P0.05);2.中医证候积分变化:两组治疗后与治疗前比较差异有统计学意义(P0.05);治疗后治疗组与对照组比较,治疗组优于对照组,差异有统计学意义(P0.05);在改善脘胁胀痛、急躁易怒、腹胀、纳呆、精神抑郁、口苦等症方面,治疗组优于对照组,两组差异有统计学意义(P0.05);在改善脘闷嗳气及烧心、泛酸、呕吐、咽部异物感等症方面,两组差异无明显统计学意义(P0.05)。3.胃电图比较:治疗组DF、N%、PR治疗后与治疗前比较均有不同程度的升高,差异有统计学意义(P0.05);对照组DF及N%治疗后与治疗前比较,均有不同程度的升高,餐前差异有统计学意义(P0.05),餐后差异无统计学意义(P0.05);对照组PR治疗后与治疗前比较,差异有统计学意义(P0.05);治疗后两组比较,N%、PR差异有统计学意义(P0.05);治疗后两组DF差异无统计学意义(P0.05)。4.不良反应观察,两组患者在治疗过程中未出现明显不良反应及毒副作用。结论:加味柴胡疏肝散能有效治疗FD肝郁气滞证患者,增强胃蠕动,促进胃排空,明显改善临床症状,安全且无毒副作用。
[Abstract]:Objective: to investigate the clinical effect of modified chaihu Shugan powder in the treatment of functional dyspepsia (stagnation of liver-qi) and its effect on electrogastrogram. Methods: from February 2015 to January 2016, 130 patients with FD liver stagnation were randomly divided into treatment group (n = 64) and control group (n = 66). The treatment group was treated with modified chaihu Shugan powder, and the control group was treated with pam Tora enteric capsule and domperidone tablet. The clinical effect, the change of TCM syndrome integral and the change of stomach electricity DFN and PR were observed and compared between the two groups after treatment. The result is 1: 1. The curative effect of disease: the total effective rate of the treatment group was 92.19%, and the total effective rate of the control group was 80.30%. The treatment group was superior to the control group, and the difference was statistically significant (P 0.05). Changes of TCM syndrome score: there was a significant difference between the two groups after treatment and before treatment; after treatment, the treatment group was better than the control group, and the difference was statistically significant (P 0.05). The treatment group was superior to the control group in the symptoms of depression, depression and bitter mouth, the difference between the two groups was statistically significant (P 0.05), but there was no significant difference between the two groups in the improvement of belching and heartburn, pantothenic acid, vomiting and foreign body sensation of pharynx. Comparison of electrogastrogram: in the treatment group, the levels of DF and N% increased in different degrees after treatment compared with those before treatment, the difference was statistically significant (P 0.05), and that in the control group and N% was higher than that before treatment. There were significant differences in preprandial and postprandial differences (P 0.05); in the control group, there was significant difference in P 0.05; after treatment, there was a significant difference in P 0.05; after treatment, there was no significant difference in DF between the two groups (P 0.05 .4). Adverse reaction observation showed that there were no obvious side effects and side effects during the treatment. Conclusion: modified chaihu Shugan powder can effectively treat FD patients with stagnation of liver qi, enhance gastric peristalsis, promote gastric emptying, improve clinical symptoms, and be safe and without toxic side effects.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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