补肾类中成药治疗老年性骨质疏松症的随机对照试验系统评价

发布时间：2018-05-28 02:04

本文选题：老年性骨质疏松症 + 中成药　；参考：《中医杂志》2017年10期

【摘要】：目的系统评价补肾类中成药治疗老年性骨质疏松症的疗效及安全性。方法检索相关期刊论文(CNKI)、中国生物医学文献数据库(CBM)、中文科技期刊全文数据库(VIP)、万方数据库、Cochrane Library、Medline、EMbase、Web of Science和临床试验注册库,筛选补肾类中成药治疗老年性骨质疏松症的随机对照试验研究,根据Cochrane评价标准和工具进行评价,并使用Rev Man5.3软件进行Meta分析。结果补肾类中成药单用或联合西医常规治疗在提高老年性骨质疏松症患者临床疗效总有效率方面比西医常规治疗具有优势[RR=1.22,95%CI(1.08,1.37),I~2=57%,P=0.002;RR=1.12,95%CI(1.05,1.20),I~2=7%,P=0.0003];在提高血磷、血钙方面,仅部分研究显示具有一定疗效。5项研究报告了中成药组有消化道症状等不良反应,但无严重不良反应和不良事件。结论补肾类中成药治疗老年性骨质疏松症的总体疗效优于单纯西医常规治疗,安全性较好。
[Abstract]:Objective to evaluate the efficacy and safety of kidney tonifying traditional Chinese medicine (TCM) in the treatment of senile osteoporosis. Methods to search the full text database of Chinese periodicals (CNKI), the Chinese Biomedical Literature Database (CBM), the full text Database of Chinese Sci-tech Journals (VIPI), the Chinese Journal of Science and Technology (CSTI) database, the Cochrane Library Medline EMbase of Science, and the clinical trial registry. A randomized controlled trial was conducted on the treatment of senile osteoporosis with traditional Chinese medicine for tonifying the kidney. According to the Cochrane evaluation criteria and tools, the Meta analysis was carried out with Rev Man5.3 software. Results the total effective rate of traditional Chinese medicine for tonifying the kidney or combining with western medicine in improving the total effective rate of senile osteoporosis patients was superior to that of routine western medicine treatment. Only a few studies showed that there were some therapeutic effects in 5 studies, but there were no serious adverse reactions and adverse events in the Chinese patent medicine group, such as digestive tract symptoms and other adverse reactions. Conclusion the general curative effect of traditional Chinese medicine for tonifying kidney in treating senile osteoporosis is better than that of western medicine alone, and the safety is better.
【作者单位】：中国中医科学院中医临床基础医学研究所;中国中医科学院针灸研究所;
【分类号】：R259

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