苦参制剂治疗银屑病疗效的meta分析

发布时间：2018-05-29 21:36

本文选题：苦参制剂 + 银屑病　；参考：《中药新药与临床药理》2017年04期

【摘要】：目的利用Meta分析探讨苦参制剂治疗银屑病的临床疗效。方法计算机检索Cochrane Library、MEDLINE、EMBASE、Web of Science、CNKI、万方、维普、CBM数据库,检索相关论文,收集苦参制剂治疗银屑病的随机对照试验(RCTs)。由2名独立人员进行文献检索,并严格评价纳入的研究并提取相关资料,使用Rev Man5.3进行Meta分析。结果共纳入15个临床RCTs,结果显示:苦参制剂组总有效率高于常规治疗方法组,银屑病面积和严重程度指数(PASI)评分低于常规治疗方法组,且苦参制剂组较阿维A胶囊组更为安全有效。结论苦参制剂治疗银屑病疗效优于常规治疗方法,并可降低复发率及不良反应发生率,但仍需要更为严格的多中心、大样本的随机双盲对照试验,提供高质量的临床证据。
[Abstract]:Objective to explore the clinical effect of Sophora flavescens preparation on psoriasis by Meta analysis. Methods the Cochrane Library MEDLINE EMBASEN Web of Science Cochrane CNKI, Wanfang, Vipric CBM database were searched, and the related papers were searched, and the RCTs were collected in the randomized controlled trial of Sophora flavescens in the treatment of psoriasis. Literature retrieval was carried out by two independent personnel, and the involved research was evaluated strictly and relevant data were extracted. Meta analysis was carried out with Rev Man5.3. Results Fifteen clinical RCTs were included. The results showed that the total effective rate in the Sophora flavescens group was higher than that in the conventional treatment group, and the psoriasis area and severity index (PASI) score was lower than that in the conventional treatment group. Compared with Avera capsule group, Sophora flavescens preparation group is more safe and effective. Conclusion the curative effect of Sophora flavescens preparation in the treatment of psoriasis is superior to that of conventional therapy, and it can reduce the recurrence rate and the incidence of adverse reactions, but it still needs a more strict multicenter, large sample randomized double-blind controlled trial to provide high quality clinical evidence.
【作者单位】：青岛大学附属医院;
【分类号】：R275.9

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