2型糖尿病氧化应激与单味中药干预研究

发布时间：2018-05-30 08:22

本文选题：型糖尿病 + 氧化应激　；参考：《时珍国医国药》2017年07期

【摘要】：2型糖尿病的主要病因是胰岛素抵抗及胰岛β细胞功能受损。氧化应激是机体促氧化物产生和清除之间出现失衡的一种状态,被认为是糖尿病发生发展的重要危险因素。在代谢过程中,高血糖、高血脂导致线粒体产生大量活性氧,其可损坏线粒体功能,引起氧化应激反应。氧化应激则通过抑制胰岛素分泌;促进β细胞凋亡;降低胰岛素基因表达水平;阻断胰岛素作用通路,导致胰岛素抵抗等方式诱导2型糖尿病的发生发展。文章从氧化应激诱导胰岛素抵抗和胰岛β细胞功能受损机制及单味中药干预抗氧化应激反应研究等3个角度进行综述,希望对2型糖尿病氧化应激发病机制有更完善的认识,并为抗氧化中草药的研究提供新思路。
[Abstract]:The main causes of type 2 diabetes are insulin resistance and impaired islet-尾-cell function. Oxidative stress, which is considered as an important risk factor for the development of diabetes mellitus, is a state of imbalance between the production and clearance of oxygen. During metabolism, hyperglycemia and hyperlipidemia lead to a large amount of reactive oxygen species (Ros) produced by mitochondria, which can damage the function of mitochondria and cause oxidative stress. Oxidative stress induces the development of type 2 diabetes mellitus by inhibiting insulin secretion, promoting 尾 cell apoptosis, reducing insulin gene expression, blocking insulin pathway and leading to insulin resistance. In this paper, the mechanism of insulin resistance induced by oxidative stress and the mechanism of islet 尾 cell function damage and the study of anti-oxidative stress response by single Chinese medicine were reviewed. It is hoped that the mechanism of oxidative stress in type 2 diabetes could be better understood. It also provides a new idea for the research of anti-oxidation Chinese herbal medicine.
【作者单位】：甘肃中医药大学;甘肃省中医药研究院;北京中医药大学教育部中医养生重点实验室;
【基金】：国家自然科学基金(No.81560764) 甘肃省中医药管理局项目(No.GZK-2016-48)
【分类号】：R259

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