健脾疏肝清热化瘀法治疗慢性萎缩性胃炎脾虚肝郁夹瘀证的临床研究

发布时间：2018-06-01 08:24

本文选题：慢性萎缩性胃炎 + 健脾疏肝清热化瘀法　；参考：《南京中医药大学》2017年硕士论文

【摘要】：目的:观察健脾疏肝清热化瘀法治疗慢性萎缩性胃炎(Chronic atrophic gastritis,CAG)脾虚肝郁夹瘀证的临床疗效,探讨健脾疏肝清热化瘀法治疗CAG的临床价值。方法:将符合西医和中医纳入标准的60例CAG患者,随机分为对照组和治疗组,每组30例,治疗组口服健脾疏肝清热化瘀方,对照组仅服用胃复春片,共治疗6个月,观察记录两组在治疗前后主要症状、次要症状、内镜病理变化,疗程结束后汇总、评估疗效、分析结果。结果:两组患者运用不同治疗方案后将其综合疗效对比,治疗组30例中,治愈5例,显效9例,有效12例,无效4例,总有效率86.67%;对照组30例中,治愈2例,显效6例,有效9例,无效13例,总有效率56.67%。两组综合疗效分析,治疗组的临床疗效优于对照组(P0.05)。两组单个临床症状积分对比,在胃脘疼痛、口苦口干、食少纳差方面,治疗组的临床疗效优于对照组(P0.05),对于胃胺及(或)胁肋部痞胀、嘈杂、心烦易怒、倦怠乏力、大便稀溏症状,两组治疗效果明显,同时两组疗效相当(P0.05)。病理疗效比较,两组均有好转,在治疗粘膜萎缩方面,治疗组疗效优于对照组(P0.05),在治疗肠化、异型增生方面,两组疗效相当(P0.05)。疗程中,所有患者均未出现不良反应。结论:健脾疏肝清热化瘀法治疗CAG效果明确,可显著改善患者不适症状,提高患者生活质量;同时可有效阻止CAG的进展,使萎缩的腺体恢复正常或者减轻其萎缩的程度。
[Abstract]:Objective: to observe the clinical effect of invigorating spleen and soothing liver and clearing away heat and removing blood stasis in treating chronic atrophic gastritis with chronic atrophic gastritis (chronic atrophic gastritis) and to explore the clinical value of strengthening spleen and soothing liver and clearing away heat and removing blood stasis in treating CAG. Methods: sixty patients with CAG were randomly divided into control group and treatment group, 30 cases in each group. The treatment group was treated with Jianpi Shugan Qiehuayu decoction, while the control group was treated with Weifuchun tablet for 6 months. The main symptoms secondary symptoms endoscopy pathological changes were observed and recorded before and after treatment the curative effect was evaluated and the results were analyzed. Results: the comprehensive curative effects of the two groups were compared after using different treatment schemes. In the treatment group, 5 cases were cured, 9 cases were markedly effective, 12 cases were effective, 4 cases were ineffective, and the total effective rate was 86.67%, while in the control group, 2 cases were cured, 6 cases marked effect. The total effective rate was 56.67. The clinical efficacy of the treatment group was better than that of the control group (P 0.05). The clinical effect of the treatment group was better than that of the control group in terms of epigastric pain, dry mouth, and poor appetite. The clinical efficacy of the treatment group was better than that of the control group (P 0.05). For stomach amine and / or hypochondrial distension, noise, irritability, tiredness and fatigue, the treatment group was more effective than the control group. The symptoms of loose stool were obvious in the two groups, and the curative effect of the two groups was similar to that of P0.05. In the treatment of mucosal atrophy, the therapeutic effect of the treatment group was better than that of the control group (P 0.05), and the curative effect of the two groups in the treatment of intestinal metaplasia and dysplasia was similar to that in the treatment of intestinal metaplasia and dysplasia. During the course of treatment, no adverse reactions were found in all patients. Conclusion: the method of invigorating spleen, soothing liver and clearing away heat and removing blood stasis is effective in the treatment of CAG, which can significantly improve the symptoms of discomfort and improve the quality of life of the patients, at the same time, it can effectively prevent the progress of CAG, restore the atrophic glands to normal or reduce the degree of atrophy.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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