基于数据挖掘技术对孙建光教授治疗慢性乙型肝炎的经验总结

发布时间：2018-06-02 09:30

本文选题：慢性乙型肝炎 + 中药治疗　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:初步探讨慢性乙型肝炎证型分布特点,总结导师治疗本病用药规律,为中医药治疗慢性乙型肝炎提供理论基础和实践依据。方法:本课题采用病例回顾性分析的方法,借助中医临床信息采集系统记录171例经治有效的慢性乙型肝炎患者的临床一般资料和处方用药,运用数据挖掘技术结合统计学进行处理,总结导师临床用药规律,并加以总结。结果:1.本次研究中,171例慢性乙型肝炎患者中男性118例,女性53例;2.本次研究中统计到中医证型6种,按频数大小排序为肝郁脾虚型肝胆湿热型肝肾阴虚型瘀血阻络型脾肾阳虚型肝郁气滞型,总体对比P0.05,有统计学意义;3.慢性乙型肝炎性别、年龄总体比较P0.05,有显著差异;4.导师临床用药规律:(1)肝胆湿热型:第一类主药为茵陈、败酱草、芦根、竹叶、黄连、黄芩,第二类为柴胡、陈皮,第三类为鸡内金、山药、薏苡仁、豆蔻,第四类为浙贝母、生牡蛎。(2)肝郁脾虚型:第一类主药为黄芪、薏苡仁、鸡内金、山药,第二类为郁金、陈皮,第三类为茵陈、败酱草、板蓝根、芦根,第四类为当归、川芎、牛膝、白芍。(3)肝肾阴虚型:第一类主药为枸杞、女贞子、旱莲草、生地黄、杜仲,第二类为鸡内金、山药、薏苡仁,第三类为茵陈、败酱草、板蓝根、竹叶、芦根,第四类为柴胡、郁金,第五类为当归、莪术。(4)瘀血阻络型:第一类主药为当归、赤芍、川芎,第二类为柴胡、枳壳、桔梗、郁金,第三类为生牡蛎、莪术、浙贝母,第四类为牛膝、生地黄、白芍,第五类为黄芪、鸡内金、山药、薏苡仁,第六类为茵陈、败酱草、板蓝根。(5)脾肾阳虚型:第一类主药为附子、桂枝;第二类熟地黄、女贞子、枸杞、山萸肉,第三类为黄芪、薏苡仁、山药、鸡内金,第四类茯苓、白术,第五类茵陈、败酱草、车前草。(6)肝郁气滞型:第一类主药为柴胡、佛手、香附、枳壳、川芎、郁金,第二类主药为鸡内金、茯苓、枳实,第三类茵陈、败酱草、板蓝根、芦根、竹叶,第四类生牡蛎、浙贝母。结论:1.运用中医临床信息采集系统可以将大量的信息(如患者的临床资料和处方用药)加以汇总,形成自己独立的数据库,方便查找,避免了数据的丢失,亦使得数据变的更加客观、真实;2.数据挖掘是总结、传承中医经验的有效途径:数据挖掘技术可以使导师的经验变的更直观、更易懂,同时还可以进行重复性的操作,这对中医学学术经验的继承以及中医学的发展创新有着极其重要的意义;3.运用数据挖掘技术分析海量的中医诊疗信息,有助于发现中医辨证施治、处方用药等环节中隐含的关键关联和规律,使得最后得出的结果更具客观真实性,更好的为中医药治疗慢性乙型肝炎提供理论基础和实践依据。4.中医临床信息采集系统和数据挖掘技术为中医对慢性乙型肝炎的研究提供了新平台,节约了劳动力,减小了误差,对中医学术水平的提高有着重大的作用。5.整理总结导师治疗慢性乙型肝炎的经验。导师认为肝郁脾虚是慢乙肝的主要病机之一,调肝健脾法贯穿于慢乙肝治疗始终;疾病后期,应注重补肾养肝;针对病因,勿忘清热利湿解毒。
[Abstract]:Objective: to preliminarily discuss the distribution characteristics of the syndrome type of chronic hepatitis B, summarize the rule of medication for the treatment of this disease, and provide the theoretical basis and practical basis for the treatment of chronic hepatitis B with Chinese medicine. Methods: this subject uses a retrospective analysis of cases and records 171 cases of chronic hepatitis B with the help of clinical information collection system of traditional Chinese medicine. The clinical general data and prescription drug use, data mining technique combined with statistics to summarize the rule of clinical medication of the tutor and summarize. Results: in 1. studies, 171 cases of chronic hepatitis B patients were 118 cases and 53 women, and 6 of the 2. studies were statistically classified as liver depression according to frequency. Spleen deficiency type liver and gallbladder damp heat type liver kidney yin deficiency type spleen kidney yang deficiency type liver qi stagnation type, overall comparison P0.05, has statistical significance; 3. chronic hepatitis B sex, age overall comparison P0.05, significant difference; (1) the liver and gallbladder damp heat type: the first type of main medicine is Artemisia, Rhizoma Patrinia, reed root, bamboo leaf, Huanglian, Scutellaria, The second category is Bupleurum bupleurum, tangerine peel, third types of chicken inner gold, yam, coix seed, nutmeg, fourth kinds of Zhejiang Fritillaria, raw oysters. (2) liver qi stagnation and spleen deficiency type: the first class main medicine is Astragalus membranaceus, coix seed, chicken inner gold, yam, the second kinds are the tulips, the third types are Yin Chen, the rhizoma Patrinia, the Radix Isatis Root, the root, the root, and the fourth types are angelica, Ligusticum chuanxiong, Achyranthes and paeony. (3) liver kidney yin Virtual type: the first type of main medicine is Lycium barbarum, Ligustrum lucidum, Rhizoma rehmanniae, Eucommia ulmoides, the second types are chicken inner gold, yam, coix seed, third kinds of Artemisia, Rhizoma Patrinia, Radix Isatidis, bamboo leaves, Ruta root, fourth types of Chaihu, tulip, fifth types of angelica, zedoary turmeric. (4) the main drug is angelica, Radix Paeoniae, chuanxiong, the second kinds of bupleurum, Fructus aurantii, Fructus aurantii, Platycodon grandiflorum, tulip, third types of oyster, zedoary turmeric, Fritillaria thunbergii, fourth kinds of Achyranthes, rehmannia, Paeonia lactiflora, fifth kinds of Astragalus, cinnamon, yam, coix seed, sixth types of Yin Chen, Patrinia, isatis root. (5) spleen and kidney yang deficiency: the first class main medicine is the Radix Aconiti, Cinnamomum, second types of cooked ground yellow, Ligustrum lucidum, Lycium barbarum, coix seed, and the third classes of Astragalus, coix seed, coix seed, and the third category of Coix seed Coix kernel Yam, chicken inner gold, fourth kinds of Poria cocos, Atractylodes macrocephala, fifth kinds of Artemisia, Patrinia, Plantago. (6) stagnation of liver Qi: the first major drugs are Radix Bupleuri, fingered, Fructus trifoliate, chuanxiong, tulip, and the second kinds of main drugs are chicken inner gold, Poria cocos, Fructus aurantii, Radix Isatidis, Radix Isatis, bamboo leaves, fourth kinds of raw oysters and Fritillaria thunbergii. Conclusion: 1. use traditional Chinese medicine (1.). Conclusion: 1. use traditional Chinese medicine. The clinical information collection system can collect a large amount of information (such as patients' clinical data and prescription drugs), form their own independent database, facilitate the search, avoid the loss of data, and make the data more objective and true. 2. data mining is an effective way to sum up and inherit the experience of traditional Chinese medicine: data mining technology can make The experience of the tutor is more intuitionistic, more easy to understand, and can also be repeated, which is of great significance to the inheritance of the academic experience of traditional Chinese medicine and the development and innovation of traditional Chinese medicine. 3. the application of data mining technology to the analysis of massive Chinese medical diagnosis and treatment information will help to find the link of TCM syndrome differentiation and prescription medication. The key correlation and rules make the final results more objective and realistic, and provide a theoretical basis and practical basis for the treatment of chronic hepatitis B by traditional Chinese medicine. The.4. clinical information collection system and data mining technology provide a new platform for the study of chronic hepatitis B, saving the labor force and reducing the error. The improvement of the academic level of Chinese medicine has a great effect on the experience of the treatment of chronic hepatitis B by.5.. The tutor thinks that the liver depression and spleen deficiency is one of the main pathogenesis of the chronic hepatitis B. The method of regulating the liver and invigorating the spleen throughout the treatment of the chronic hepatitis B; the later period of the disease should pay attention to the nourishing the kidney and nourishing the liver; for the cause of the disease, you should not forget to clear the heat, wet the detoxification of the dampness and the dampness.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R249;R259

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