桂枝寤汤和桂枝寐汤治疗不寐的临床研究

发布时间：2018-06-02 23:04

  本文选题：桂枝寤汤 + 桂枝寐汤　； 参考：《福建中医药大学》2016年博士论文

【摘要】：目的：通过对桂枝寤汤和桂枝寐汤治疗不寐的临床研究,归纳总结桂枝寤汤和桂枝寐汤治疗不寐疗效差异相关影响因素,不断改进桂枝寤汤和桂枝寐汤组成及应用,有针对性地提高其治疗不寐的有效率。方法：选取从2015年3月至2016年3月在马来西亚霹雳州怡保市仁爱医院与星联养生堂门诊就诊并且符合中华中医药学会发布的2008年版《中医内科常见病诊疗指南·中医病证部分》不寐诊断依据、2001年版《中国精神障碍分类与诊断标准第三版》制定的失眠诊断标准的100例失眠症患者,参照2002年《中药新药临床研究指导原则(试行)》中“中药新药治疗失眠的临床研究指导原则”及WHO最新颁布的失眠临床疗效判断标准评定,将符合诊断标准及纳入、排除标准且病历资料登记完整并服用桂枝寤汤、桂枝寐汤者分为总有效组和无效组,进行有效率统计,并从一般资料和症状(包括主要症状和次要症状)两大方面进行单因素统计,将有意义的单因素再进行多因素logistic回归分析,最后筛选出具有统计学意义的影响因素。结果：1、一般资料统计分析：本次研究根据纳入和排除标准,经收集整理,删除资料丢失或者登记不完整及失访病例,共纳入100例完整病例,其中总有效组88例,占88%,无效组12例,占12%；一般资料单因素分析,结果提示：总有效组和无效组在年龄、教育程度、PSQI分数三个项目上有统计学意义(P0.05)。2、主要症状及次要症状统计分析：四大主要症状单因素统计分析,结果提示：入睡时间以一小时为界限具有统计学意义(P0.05)。次要症状单因素分析,结果提示：晨起思睡、注意力不集中、精神不振、心悸、恶风、盗汗六个项目具有统计学意义(P0.05)；3、多因素logistic回归分析：筛选出年龄、PSQI分数、晨起思睡和盗汗有统计学意义(P0.05)。结论：1、桂枝寤汤和桂枝寐汤对不寐具有明确的疗效。2、桂枝寤汤和桂枝寐汤对PSQI分数低,有晨起思睡、盗汗的老年失眠人群有更好的疗效。
[Abstract]:Objective: through the clinical study of Guizhiwu decoction and Guizhimian decoction in the treatment of insomnia, the related factors related to the curative effect of Guizhiwu decoction and Guizhimian decoction in treating insomnia were summarized, and the composition and application of Guizhiwu decoction and Guizhimi decoction were improved continuously. Improve the effective rate of treatment of insomnia. Methods: selected from March 2015 to March 2016, at Ipoh Hospital in Perak, Malaysia, and in accordance with the 2008 edition of the guidelines for diagnosis and treatment of Common Diseases in traditional Chinese Medicine issued by the Chinese Association of traditional Chinese Medicine. The part of TCM disease and syndrome > the basis for diagnosis of insomnia, the third edition of the Chinese Classification and Diagnostic Standard of Mental Disorder, 2001, 100 cases of insomnia diagnosed by the standard of insomnia, the third edition of the 2001 edition of the Chinese Psychiatric Classification and Diagnostic Standard, According to the "guiding principles of Clinical Research of New Chinese Medicine (trial)" in 2002, "guiding principles of Clinical Research on Insomnia treated by New drugs of traditional Chinese Medicine" and the evaluation of clinical curative effect of insomnia promulgated by WHO, it will meet the diagnostic criteria and be included in the evaluation. The patients were divided into general effective group and ineffective group, and the effective rate was counted. Univariate statistics were carried out from general data and symptoms (including main symptoms and secondary symptoms), and then multivariate logistic regression analysis was carried out on significant single factors. Finally, statistically significant influencing factors were screened out. Results: according to the criteria of inclusion and exclusion, this study included 100 cases of complete cases, including 88 cases in the effective group, after collecting and sorting out the missing data or incomplete registration and missing cases. There were 12 cases in the ineffective group, 12 cases in the ineffective group, and the results showed that the total effective group and the ineffective group were in the age, There was statistical significance in three items of educational level and PSQI score: the statistical analysis of main symptoms and secondary symptoms: four major symptoms were single factor statistical analysis, the results indicated that the limit of falling asleep time was one hour, which had statistical significance (P 0.05). The results of univariate analysis of secondary symptoms showed that six items, such as thinking and sleeping early in the morning, inattention loss, mental retardation, palpitation, bad wind and night sweating, had statistical significance (P 0.05). Multivariate logistic regression analysis showed that age and age were determined by logistic regression analysis. There was significant difference between sleep and night sweating in the morning (P 0.05). Conclusion: 1, Guizhiwu decoction and Guizhimian decoction have definite curative effect on insomnia. Guizhiwu decoction and Guizhimian decoction have better effect on senile insomnia with low PSQI score, early morning sleep and night sweating.
【学位授予单位】：福建中医药大学
【学位级别】：博士
【学位授予年份】：2016
【分类号】：R256.23
，

本文编号：1970532