肠炎愈汤直肠灌注治疗湿热蕴结证溃疡性直肠炎的临床研究

发布时间：2018-06-04 02:45

本文选题：肠炎愈汤 + 湿热蕴结证　；参考：《湖南中医药大学》2016年硕士论文

【摘要】：目的:探讨肠炎愈汤直肠灌注治疗湿热蕴结证溃疡性直肠炎的临床疗效及安全性。方法:随机从2015年5月~2015年11月选取符合湿热蕴结证溃疡性直肠炎诊断标准的60例门诊患者为研究对象,按随机数字法分为对照组和治疗组。其中对照组予中药清肠活血汤直肠灌注治疗,治疗组予中药肠炎愈汤直肠灌注治疗,观察两组治疗后临床疗效及安全性。结果:(1)一般资料结果:两组一般资料(性别、年龄、病程、治疗史、治疗前病情轻重程度)差异比较无统计学意义(P0.05),具有可比性。(2)实验结果:对照组治疗后主要症状腹泻、黏液便、肛门坠胀积分分别为(1.40±0.81)分、(1.53±0.68)分、(1.46±0.73)分,治疗组主要症状腹泻、黏液便、肛门坠胀积分分别为(0.80±0.76)分、(0.86±0.73)分、(0.83±0.74)分,治疗组主要症状积分均改善均高于对照组(P0.05),有统计学意义。两组经不同治疗后肠镜黏膜病变积分改变无统计学意义(P0.05)。对照组治疗后中医证候积分平均(6.00±1.43)分,治疗组(3.80±1.18)分,两组中医证候积分差异比较有统计学意义(P0.05)。对照组总有效率73.3%,治疗组93.4%,两组差异比较有统计学意义(P0.05)。两组在治疗过程中均未出现严重不良反应,安全性高。结论:肠炎愈汤直肠灌注治疗湿热蕴结证溃疡性直肠炎疗效确切,安全性高,能有效改善患者腹泻、黏液便、肛门坠胀主要临床症状。
[Abstract]:Objective: to investigate the clinical efficacy and safety of Changchangyu decoction (YYT) in the treatment of ulcerative proctitis with damp-heat accumulation syndrome. Methods: from May 2015 to November 2015, 60 outpatients with ulcerative colitis of damp-heat accumulation syndrome were randomly selected and divided into control group and treatment group. The control group was treated with rectal perfusion of Qingchang Huoxue decoction and the treatment group was treated with the traditional Chinese medicine Changyu decoction. The clinical efficacy and safety of the two groups were observed. Results: there was no significant difference in general data (sex, age, course of disease, history of treatment, severity of illness before treatment) between the two groups (P 0.05). The scores of mucus stool and anal drop distension were 1.40 卤0.81) and 1.53 卤0.68 respectively. The main symptoms of diarrhea, mucus and anal bloating were 0.80 卤0.76, 0.86 卤0.74) in the treatment group, respectively. The main symptom scores in the treatment group were all higher than those in the control group (P 0.05), with statistical significance. After different treatment, there was no significant change of mucosal lesion score in the two groups (P 0.05). The average score of TCM syndromes in the control group was 6.00 卤1.43, and that in the treatment group was 3.80 卤1.18. The difference of TCM syndromes between the two groups was statistically significant (P 0.05). The total effective rate was 73.3% in the control group and 93.4% in the treatment group. The difference between the two groups was statistically significant (P 0.05). There was no serious adverse reaction in both groups and the safety was high. Conclusion: the rectal perfusion of Changyan Yu decoction is effective and safe in treating ulcerative proctitis with dampness and heat accumulation syndrome. It can effectively improve the main clinical symptoms of diarrhea, mucus stool and anal dropsy.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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