温肺化痰汤对AECOPD（阳虚痰盛夹热证）的临床疗效观察及对血清IL-23的影响

发布时间：2018-06-04 10:22

本文选题：温肺化痰汤 + AECOPD　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:观察温肺化痰汤对AECOPD(阳虚痰盛夹热证)的临床疗效及对血清IL-23的影响。方法:选择于黑龙江中医药大学附属第一医院门诊就诊的68例AECOPD(阳虚痰盛夹热证)患者,应用随机单盲法将患者分为治疗组(34例)和对照组(34例),两组均口服西药头孢克洛和多索茶碱,同时治疗组给予温肺化痰汤,对照组给予参贝咳喘丸。疗程为10天。观察两组患者在用药前后临床症状的改善、肺功能、白细胞计数、综合疗效评估及血清IL-23的变化情况。结果:1.温肺化痰汤治疗AECOPD(阳虚痰盛夹热证)临床疗效显著,其总有效率为93.75%,与对照组比较有统计学意义(P0.05),疗效明显优于对照组,无不良反应。2.温肺化痰汤可有效改善患者中医证候,尤其在咳嗽、咯黄痰、畏寒肢冷及气短喘息方面,且治疗组疗效更加显著(P0.05)。3.两组药物可相对提升患者疗前疗后的FEV1及 FEV1/FVC的数值,但疗前疗后相比无统计学意义(P0.05)。4.两组患者疗前疗后白细胞计数均下降,且组内比较有统计学意义(P0.05);疗后组间比较有统计学意义(P0.05),且治疗组优于对照组。5.两组药物均可有效改善患者综合评估,疗前疗后比较有统计学意义(P0.05),疗后组间比较无统计学意义(P0.05),但治疗组改善程度优于对照组。6.两组药物均能降低患者血清中IL-23含量,疗前疗后相比有统计学意义(P0.05)。组间比较,治疗组明显优于对照组(P0.05)。结论:1.温肺化痰汤治疗AECOPD(阳虚痰盛夹热证)临床疗效显著,可显著改善患者的临床症状,尤其在咳嗽、咯黄痰、畏寒怕冷方面。2.温肺化痰汤可降低患者白细胞计数以及改善患者综合评估程度。3.温肺化痰汤可有效降低AECOPD(阳虚痰盛夹热证)患者血清中IL-23的表达。
[Abstract]:Objective: to observe the clinical effect of Wenfei Huatan decoction (WFHuatang) on AECOPDD (Yang deficiency and phlegm with heat retention syndrome) and the effect of WFHuatan decoction on serum IL-23. Methods: Sixty-eight patients with AECOPD (Yang deficiency phlegm and heat syndrome) were selected from the outpatient clinic of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine. The patients were randomly divided into treatment group (n = 34) and control group (n = 34). Both groups were treated by oral administration of cefaclor and doxophylline. The treatment group was given Wenfei Huatan decoction and the control group was given Shenbei Kechuan pills. The course of treatment was 10 days. The improvement of clinical symptoms, pulmonary function, white blood cell count, comprehensive evaluation of curative effect and changes of serum IL-23 were observed before and after treatment. The result is 1: 1. The clinical curative effect of Wenfei Huatan decoction in treating AECOPD (Yang deficiency and phlegm with heat) was remarkable, the total effective rate was 93.755.Compared with the control group, the effect was significantly better than that of the control group, and the curative effect was obviously better than that of the control group, and there was no adverse reaction. 2. Wenfei Huatan decoction can effectively improve the TCM syndromes, especially in cough, yellow phlegm, cold limbs and short breath, and the curative effect of the treatment group is more obvious than that of P0.05. 3. The FEV1 and FEV1/FVC of the two groups were significantly higher than that of the patients before and after treatment, but there was no significant difference between the two groups before and after treatment (P 0.05. 4). Before and after treatment, the white blood cell count decreased in both groups, and there was significant difference between the two groups (P 0.05), and the treatment group was better than the control group (P 0.05). Two groups of drugs can effectively improve the comprehensive evaluation of patients, before and after treatment compared with P0.05, there is no significant difference between the treatment group P0.05, but the treatment group is better than the control group. 6. Both groups could reduce the IL-23 content in the serum of the patients, and there was significant difference between the two groups before and after treatment (P 0.05). Compared with the control group, the treatment group was better than the control group (P 0.05). Conclusion 1. Wenfei Huatan decoction has a significant clinical effect on AECOPDD, which can improve the clinical symptoms of the patients, especially in cough, yellow phlegm, chills and cold. Wenfei Huatan decoction can reduce the white blood cell count and improve the comprehensive evaluation of patients. Wenfei Huatan decoction can effectively reduce the expression of IL-23 in serum of AECOPD patients.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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