脱敏汤治疗肺脾气虚型变应性鼻炎的临床研究

发布时间：2018-06-04 13:04

本文选题：脱敏汤 + 变应性鼻炎　；参考：《西南医科大学》2017年硕士论文

【摘要】：目的:探讨脱敏汤对肺脾气虚型变应性鼻炎的临床疗效,对患者治疗有效率及症状改善情况进行评价,以期为脱敏汤治疗变应性鼻炎提供临床观察数据。方法:随机对照方法,在两个中心(1、西南医科大学附属中医院;2、江津区中医院)各选取肺脾气虚型变应性鼻炎确诊病例60例为研究对象,按照数字随机分为对照组60例与治疗组60例。对照组采用口服依巴斯汀片,每天一次,每次10mg,和丙酸氟替卡松鼻喷剂,每天一次,每次50ug,连续4周以上。治疗组采用孙永东教授自拟脱敏汤治疗(黄芪、白术、党参、防风、蝉蜕、茯苓、甘草、五味子、桂枝、细辛等),每天一剂,连续4周以上。治疗2周和4周后,通过卡方检验比较两组患者总有效率,以及通过视觉模拟量表(VAS)和中医主要症状体征记分比较两组患者临床症状改善情况,并进行统计学分析。结果:(1)对照组总有效率为71.7%(43/60),治疗组总有效率为95%(57/60)。对照组患者治疗有效率显著低于治疗组,P=0.0270.05,差异有统计学意义。(2)主要中医症状体征积分比较:两组患者中医症状体征积分都出现下降,2周后随访治疗组鼻塞、打喷嚏及鼻粘膜肿胀症状较对照组改善明显。4周后随访治疗组各症状积分较对照组明显下降,P0.05,差异有统计学意义。(3)患者VAS评分比较:在完成治疗4周后进行比较,两组患者VAS评分都出现下降,但治疗组VAS评分显著低于对照组,P0.05,差异有统计学意义。结论:脱敏汤能显著改善变应性鼻炎患者临床症状和体征。
[Abstract]:Objective: to investigate the clinical effect of desmin decoction on allergic rhinitis with deficiency of lung and spleen qi, and to evaluate the effective rate of treatment and the improvement of symptoms in order to provide clinical observation data for the treatment of allergic rhinitis with desmin decoction. Methods: 60 cases of allergic rhinitis with deficiency of lung and spleen qi were selected from two centers, affiliated Hospital of traditional Chinese Medicine of Southwest Medical University and Hospital of traditional Chinese Medicine in Jiang Jin District. 60 cases of allergic rhinitis of lung and spleen qi deficiency were selected as the study objects. The patients were randomly divided into control group (n = 60) and treatment group (n = 60). The control group was treated with oral Ebastine once a day, 10 mg / time, and fluticasone propionate nasal spray once a day, 50 ugs per day for more than 4 weeks. The treatment group was treated with Professor Sun Yongdong's self-made desensitization decoction (Astragalus, Atractylodes macrocephala, Codonopsis, Fangfeng, Cicada slough, Poria cocos, Licorice, Schisandra chinensis, Cinnamon, Asarum, etc., one dose per day for more than 4 weeks. After 2 weeks and 4 weeks of treatment, the total effective rate of the two groups was compared by chi-square test, and the improvement of clinical symptoms was compared by visual analogue scale (VASS) and the score of main symptoms and signs of traditional Chinese medicine (TCM), and the statistical analysis was carried out. Results the total effective rate of the control group was 71.7% and the total effective rate of the treatment group was 95 / 57 / 60. The effective rate of treatment in the control group was significantly lower than that in the treatment group (P < 0.0270.05). The difference was statistically significant. The symptoms of sneezing and swelling of nasal mucosa were improved significantly after 4 weeks compared with the control group. The scores of symptoms in the treatment group were significantly lower than those in the control group (P 0.05). The difference was statistically significant (P < 0.05). Comparison of the VAS scores of the patients: after 4 weeks of treatment, the scores were compared. The VAS score of the two groups decreased, but the VAS score in the treatment group was significantly lower than that in the control group (P 0.05). Conclusion: desmin decoction can significantly improve the clinical symptoms and signs of allergic rhinitis.
【学位授予单位】：西南医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R276.1

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