加味二陈平胃散治疗支扩继发感染（痰浊阻肺夹热证）的临床观察及对CRP的影响

发布时间：2018-06-04 17:14

本文选题：加味二陈平胃散 + 支扩继发感染痰浊阻肺夹热证　；参考：《黑龙江中医药大学》2016年硕士论文

【摘要】：目的：观察加味二陈平胃散治疗支气管扩张继发感染(痰浊阻肺夹热证)患者的临床症状、体征的改变及对血清中CRP的影响。方法：选择符合支气管扩张继发感染(痰浊阻肺夹热证)患者72例,随机分为治疗组36例和对照组36例。实际完成人数治疗组35例,1例剔除(因违背试验方案),对照组34例,2例脱落(1例失访,1例病情加重)。对照组给予拜复乐及切诺口服治疗,治疗组在对照组的基础上给予加味二陈平胃散中药汤剂。观察患者治疗前后的临床症状、体征,ELISA法检测患者治疗前后血清中CRP含量的改变。结果：1.加味二陈平胃散治疗支气管扩张继发感染(痰浊阻肺夹热证)临床疗效显著,其总有效率分别为：治疗组94.29%,对照组76.47%。两组比较差异显著,有统计学意义(P0.05)。2.加味二陈平胃散可显著改善支气管扩张继发感染(痰浊阻肺夹热证)患者的临床症状,特别在改善胸闷、脘痞、纳呆等方面,治疗组明显优于对照组(P0.05)。3.两组患者治疗前后肺部Up音均有改善,但两组比较无显著差异,无统计学意义(P0.05)。4.两组患者治疗前后WBC及NEUT％的值均明显下降,组间比较无显著差异(P0.05)。5.两组患者治疗前后血清中CRP含量明显下降,且治疗组与对照组比较有显著差异(P0.05)。6.两组患者治疗前后安全性指标无明显异常。结论：1.加味二陈平胃散对支扩继发感染(痰浊阻肺夹热证)患者的临床疗效显著,特别对咳嗽、咳痰、胸闷、脘痞、纳呆症状有明显改善。2.加味二陈平胃散能有效降低支扩继发感染(痰浊阻肺夹热证)患者血清中CRP的含量。
[Abstract]:Objective: to observe the changes of clinical symptoms and signs in patients with bronchiectasis secondary infection (phlegm turbid obstruction of lung heat entrapment) treated with Jiawei er Chen Ping Wei San and its effect on serum CRP. Methods: 72 cases of bronchiectasis secondary infection (phlegm turbid obstruction of lung heat) were randomly divided into treatment group (36 cases) and control group (36 cases). In the treatment group, 35 cases were removed from the treatment group and 1 case was removed. (34 cases in the control group were removed and 1 case lost one case, 1 case became worse. The control group was treated with Baifule and Chenuo orally, the treatment group was treated with Jiawei er Chen Ping Wei San decoction on the basis of the control group. To observe the clinical symptoms and signs of the patients before and after treatment and to detect the changes of serum CRP levels before and after treatment by enzyme-linked immunosorbent assay (Elisa). The result is 1: 1. The clinical efficacy of Jiawei er Chen Ping Weisan in treating bronchiectasis secondary infection (phlegm turbid obstruction of lung heat entrapment syndrome) was remarkable. The total effective rate was 94.29 in the treatment group and 76.477in the control group. The difference between the two groups was significant (P 0.05. 2). Jiawei er Chen Ping Weisan could significantly improve the clinical symptoms of patients with bronchiectasis secondary infection (phlegm turbid obstruction of lung heat entrapment syndrome), especially in the improvement of chest tightness, epigastric distension and insufflation, the treatment group was significantly better than the control group (P0.05G. 3). There was no significant difference between the two groups before and after treatment, but there was no significant difference between the two groups. Before and after treatment, the values of WBC and NEUT% were significantly decreased in both groups, and there was no significant difference between the two groups (P 0.05. 5). The level of serum CRP in the two groups decreased significantly before and after treatment, and there was a significant difference between the treatment group and the control group (P 0.05. 6). Before and after treatment, the safety indexes of the two groups were not significantly abnormal. Conclusion 1. The clinical effect of Jiawei er Chen Ping Weisan on patients with secondary infection (phlegm turbid obstruction of lung and heat entrapment) was significant, especially for cough, expectoration, chest tightness, epigastric distension and anorexia. Jiawei er Chen Ping Weisan powder can effectively reduce the content of CRP in serum of patients with secondary infection (phlegm turbid obstruction of lung heat).
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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