穴位敷贴治疗慢性稳定性心绞痛的随机对照研究

发布时间：2018-06-04 19:47

本文选题：穴位敷贴 + 慢性稳定性心绞痛　；参考：《成都中医药大学》2016年硕士论文

【摘要】：目的：本研究以慢性稳定性心绞痛患者为研究对象,采用随机对照的方法,评价穴位敷贴治疗慢性稳定性心绞痛患者的临床疗效和安全性,为穴位敷贴治疗慢性稳定性心绞痛的临床决策和临床治疗方案的优化提供有力证据。方法：将纳入试验的160例患者随机分为药物敷贴组(A组)和安慰贴对照组(B组),试验组采用冠心苏合香丸加减所制成的中药穴位敷贴进行治疗,对照组采用安慰贴治疗,两组均选取内关、膻中、心俞和厥阴俞,均单侧取穴,左右交替使用；每周3次为一个疗程,每一疗程间隔2天,连续治疗4个疗程,共12次。分别于基线期、治疗后(4周)、随访期(8周)对慢性稳定性心绞痛患者情况进行评价。评价的主要指标为心绞痛发作次数,次要指标包括心绞痛疼痛分级、VAS评分、硝酸甘油使用频次、SAQ评分、试验疗效评价和试验后症状改善情况等。结果：(1)本试验完成良好,两组分组均衡,基线状况良好,具有可比性。(2)A组治疗后与基线期相比,在心绞痛发作次数、心绞痛疼痛分级、VAS评分、硝酸甘油使用频次、SAQ评分(心绞痛稳定状态、心绞痛发作状况、治疗满意程度和疾病认知度)等方面差异具有统计学意义(P0.05)；在SAQ评分(躯体活动受限程度)方面差异不具有统计学意义(P0.05)；A组随访期与基线期比较,在心绞痛发作次数、心绞痛疼痛分级、VAS评分、硝酸甘油使用频次、SAQ评分(躯体活动受限程度、心绞痛绞痛稳定状态、治疗满意程度和疾病认知度)方面差异具有统计学意义(P0.05)；在SAQ评分(心绞痛发作状况)方面差异不具有统计学意义(P0.05)。(3)B组治疗后与基线期比较,在心绞痛发作次数、VAS评分、硝酸甘油使用频次、SAQ评分(疾病认知度)等方面差异不具有统计学意义(P0.05)；在SAQ评分(躯体活动受限程度、心绞痛绞痛稳定状态、心绞痛发作状况和治疗满意程度)等方面差异具有统计学意义(P0.05)；B组随访期与基线期比较,在心绞痛发作次数、VAS评分、硝酸甘油使用频次、SAQ评分(躯体活动受限程度、心绞痛稳定状态)等方面差异不具有统计学意义(P0.05)：在SAQ评分(心绞痛发作状况、治疗满意程度和疾病认知度)方面差异具有统计学意义(P0.05)。(3)治疗后,A组与B组比较,在心绞痛发作次数、心绞痛疼痛分级、VAS评分、硝酸甘油使用频次、SAQ评分(心绞痛绞痛稳定状态、心绞痛发作状况、治疗满意程度和疾病认知度)等方面差异具有统计学意义(P0.05)；在SAQ评分(躯体活动受限程度)等方面差异不具有统计学意义(P0.05)；随访期,A组与B组比较,在心绞痛发作次数、心绞痛疼痛分级、VAS评分、硝酸甘油使用频次、SAQ评分(躯体活动受限程度、心绞痛绞痛稳定状态、心绞痛发作状况、治疗满意程度和疾病认知度)、试验疗效评价和症状改善情况等方面差异具有统计学意义(P0.05)。结论：以冠心苏合香丸加减所制成的穴位敷贴对改善慢性稳定性心绞痛患者临床症状具有显著效果,可改善患者的心绞痛发作次数、心绞痛疼痛分级、VAS评分、硝酸甘油使用频次、SAQ评分等,在缓解患者心绞痛症状的同时,对患者生活质量的提高也起到了重要的作用；穴位敷贴是一种安全的治疗手段,可作为慢性稳定性心绞痛的防治的辅助措施。
[Abstract]:Objective: To evaluate the clinical efficacy and safety of Acupoint Application in the treatment of chronic stable angina pectoris patients with chronic stable angina, and to provide effective evidence for the treatment of chronic stable angina pectoris by Acupoint Application in the treatment of chronic stable angina pectoris. The 160 patients were randomly divided into drug application group (group A) and consolation group (group B). The experimental group was treated with Acupoint Application of Chinese medicine with Guanxin souxiang pill. The control group was treated with consolation paste, and the two groups were selected from Neiguan, Shan Zhong, Xinyu and Yueyin Yu. They were both unilateral and left and right. 3 times a week were used. A course of treatment, 2 days interval, 4 consecutive courses, 12 times. At baseline, after treatment (4 weeks), follow-up period (8 weeks) of patients with chronic stable angina pectoris. The main index of the evaluation was the frequency of angina pectoris, secondary indexes including angina pectoris classification, VAS score, frequency of nitroglycerin use, SAQ evaluation. Results: (1) the results were as follows: (1) the experiment was completed well, the two groups were balanced, the baseline was good and comparable. (2) after the treatment of group A, the number of angina pectoris, the classification of angina pain, the score of VAS, the frequency of nitroglycerin, the SAQ score (the stable state of angina pectoris, the heart of the heart) The differences in pain attack status, treatment satisfaction and disease recognition were statistically significant (P0.05), and there was no statistical significance in SAQ score (P0.05); in group A, the number of angina pectoris, angina pectoris grade, VAS score, frequency of nitroglycerin use, SA The difference in Q score (physical activity limitation, angina pectoris stability, treatment satisfaction and disease recognition) was statistically significant (P0.05), and there was no statistical significance in SAQ score (P0.05). (3) compared with the baseline period, the number of angina pectoris, the VAS score, and the Gump of nitric acid in the B group were compared with the B group. There was no statistical significance (P0.05) in the frequency of oil use, SAQ score (disease recognition) and other aspects. The difference in SAQ score (physical activity limitation, angina pectoris stability, angina pectoris condition and treatment satisfaction) was statistically significant (P0.05). Group B was compared with baseline period in angina pectoris attack. The number, VAS score, the frequency of nitroglycerin use, the SAQ score (the degree of physical activity limitation, the stable state of angina pectoris) were not statistically significant (P0.05): the difference between the SAQ score (angina pectoris condition, treatment satisfaction and disease recognition) was statistically significant (P0.05). (3) after the treatment, the A group was compared with the B group in the cardiac stranding. The number of pain attacks, angina pectoris classification, VAS score, frequency of nitroglycerin use, SAQ score (angina pectoris stable state, angina pectoris condition, treatment satisfaction and disease recognition) were statistically significant (P0.05), and there was no statistical significance in SAQ score (body activity limitation), and so on (P0.05 During the follow-up period, the A group was compared with the B group, including the frequency of angina pectoris, the classification of angina pain, the VAS score, the frequency of nitroglycerin, the SAQ score (the degree of physical activity limitation, the stable state of angina pectoris, the condition of angina pectoris, the condition of angina pectoris, the cognition of the disease, and the cognition of the disease), and the difference of the evaluation of the efficacy and the improvement of the symptoms. Statistical significance (P0.05). Conclusion: acupoint application made with the addition and subtraction of Guanxin Su Xiang pill has significant effect on improving the clinical symptoms of chronic stable angina patients. It can improve the frequency of angina pectoris, pain classification of angina pectoris, VAS score, frequency of nitroglycerin use, SAQ score and so on, in alleviating the symptoms of angina pectoris in patients. It also plays an important role in improving the quality of life of the patients, and acupoint application is a safe treatment method, which can be used as an auxiliary measure for the prevention and treatment of chronic stable angina.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R246.1

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