益肾活血化痰方对2型糖尿病合并颈动脉粥样硬化患者的影响

发布时间：2018-06-05 06:45

本文选题：益肾活血化痰方 + 型糖尿病　；参考：《中国中西医结合杂志》2017年11期

【摘要】：目的观察益肾活血化痰方对2型糖尿病(T2DM)合并颈动脉粥样硬化(CAS)患者的影响。方法将T2DM合并CAS的患者随机分为治疗组132例,对照组136例。最终纳入病例数为治疗组124例,对照组133例。对照组予西药基础治疗;治疗组在对照组治疗基础上予中药益肾活血化痰方。两组均观察用药12周。进行中医证候疗效判断,观察颈动脉内中膜厚度(IMT)、颈动脉斑块数目、颈动脉血流速度[颈总动脉舒张期最小血流速度(Vmin)、收缩期最大血流速度(Vmax)和阻力指数(RD)]及血生化指标[空腹血糖(FBG)、糖基化血红蛋白(HbA1c)、TC、LDL-C、TG]。结果治疗后,对照组中医证候疗效总有效率为54.14%(72/133),治疗组为65.32%(81/124),治疗组高于对照组(P0.05)。与本组治疗前比较,两组治疗后TC、TG、LDL、FBG及HbA1c水平降低,治疗组颈动脉IMT、斑块数目、RD及对照组斑块数目均减少,治疗组Vmax、Vmin增加(P0.05)。与对照组同期比较,治疗组治疗后颈动脉IMT、斑块数目及RD减少,Vmax增加(P0.05)。结论益肾活血化痰方对T2DM合并CAS患者的临床生化指标、中医证候及颈动脉内中膜厚度、斑块数目、血流速度、血流阻力等方面有一定疗效。
[Abstract]:Objective to observe the effect of Yishen Huoxue Huatan recipe on type 2 diabetes mellitus (T2DM) with carotid atherosclerosis (CAS). Methods T2DM patients with CAS were randomly divided into treatment group (n = 132) and control group (n = 136). The final cases included 124 cases in the treatment group and 133 cases in the control group. The control group was treated with western medicine and the treatment group was treated with Yishen Huoxue Huatan prescription. Both groups were observed for 12 weeks. To judge the curative effect of TCM syndromes, observe the IMT thickness of carotid artery and the number of carotid plaques. Carotid artery blood flow velocity [minimum diastolic velocity of common carotid artery (Vmin), maximal systolic velocity (Vmax) and resistance index (RD)] and blood biochemical indexes [fasting blood glucose (FBGG), glycosylated hemoglobin (HbA1cU), TbA1ctroglyceride]. Results after treatment, the total effective rate of TCM syndromes in the control group was 54.14% and that in the treatment group was 65.32 / 121 / 124, which was higher than that in the control group (P 0.05). Compared with those before treatment, the levels of HbA1c and TGG LDLBG in the two groups were decreased, the number of carotid artery IMT, plaque number and the number of plaques in the control group were decreased, and Vmax Vmin was increased in the treatment group (P 0.05). Compared with the control group, IMT, plaque number and Rd decreased in the treatment group after treatment. Conclusion Yishen Huoxue Huatan recipe has certain curative effect on the clinical biochemical index, TCM syndrome, carotid artery intima media thickness, plaque number, blood flow velocity and blood flow resistance of T2DM patients with CAS.
【作者单位】：福建医科大学附属协和医院中医科;
【分类号】：R259

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