香砂六君子汤联合针刺疗法治疗功能性消化不良临床疗效观察

发布时间：2018-06-05 13:13

本文选题：功能性消化不良 + 脾胃气虚证　；参考：《中国实验方剂学杂志》2017年20期

【摘要】：目的:观察和评价香砂六君子汤联合针刺疗法治疗脾胃气虚证功能性消化不良的临床疗效及其对患者血浆胃动素(MOT)和血清胃泌素(GAS)水平的影响。方法:选取2014年1月—2016年8月在广西中医药大学附属瑞康医院消化内科住院被诊断为脾胃气虚证功能性消化不良的120例患者,按照随机数字表法分为治疗组(62例)和对照组(58例)。治疗组采用口服香砂六君子汤联合针刺疗法治疗,对照组给予口服盐酸伊托必利分散片联合复方阿嗪米特肠溶片治疗,2周为1疗程,两组患者连续治疗2个疗程,治疗结束后对两组中临床痊愈的患者进行为期2个月的随访。观察并分析比较两组患者的中医证候积分、临床总体疗效、血浆MOT和血清GAS水平变化、汉密尔顿焦虑量表(HAMA)评分和17项汉密尔顿抑郁量表(HAMD-17)评分、不良反应以及远期疗效。结果:治疗结束后,治疗组患者中医证候积分,HAMA评分和HAMD-17评分均明显低于对照组(P0.05);治疗组临床疗效总有效率为88.71%,高于对照组的74.14%(P0.05);治疗组患者血浆MOT水平明显高于对照组(P0.05),血清GAS水平明显低于对照组(P0.05);两组患者治疗期间均未出现明显的不良反应;治疗组病情复发率为11.11%,明显低于对照组的44.44%(P0.05)。结论:香砂六君子汤联合针刺疗法治疗脾胃气虚证功能性消化不良可以显著提高临床疗效,安全性好,能够改善患者焦虑抑郁状态,并且能够提高远期疗效,其作用机制可能与升高血浆MOT水平和降低血清GAS水平相关。
[Abstract]:Objective: to observe and evaluate the clinical efficacy of Xiangsha Liujunzi decoction combined with acupuncture therapy in the treatment of functional dyspepsia with deficiency of spleen and stomach qi and its effect on plasma motilin (motilin) and serum gastrin (gastrin) GAS. Methods: from January 2014 to August 2016, 120 patients with functional dyspepsia of spleen and stomach qi deficiency syndrome were selected from the Department of Digestive Medicine, Ruikang Hospital affiliated to Guangxi University of traditional Chinese Medicine, in which 120 patients were diagnosed as functional dyspepsia. According to the random number table method, the treatment group (62 cases) and the control group (58 cases) were divided into two groups. The treatment group was treated by oral Xiangsha Liujunzi decoction combined with acupuncture therapy, the control group was treated with itopride hydrochloride dispersible tablets and compound azinomide enteric coated tablets for 2 weeks as a course of treatment, and the two groups were treated continuously for 2 courses. Patients in both groups were followed up for 2 months after treatment. The scores of TCM syndromes, total clinical efficacy, plasma MOT and serum GAS levels, the scores of Hamilton anxiety scale (Hama) and 17 items of Hamilton Depression scale (Hamilton Depression scale), adverse reactions and long-term effects were observed and compared between the two groups. Results: after the treatment, Hama scores and HAMD-17 scores of TCM syndromes in the treatment group were significantly lower than those in the control group (P 0.05), the total effective rate in the treatment group was 88.71, which was higher than that in the control group (74.14%), the plasma MOT level in the treatment group was significantly higher than that in the control group (P 0.05), and the serum GAS level in the treatment group was significantly higher than that in the control group (P 0.05). It was significantly lower than that in the control group (P 0.05), and there were no significant adverse reactions in both groups during the treatment period. The relapse rate of the treatment group was 11.11%, which was significantly lower than that of the control group (44.44% P 0.05). Conclusion: Xiangsha Liujunzi decoction combined with acupuncture therapy in the treatment of functional dyspepsia of spleen and stomach qi deficiency syndrome can significantly improve the clinical efficacy and safety, can improve the anxiety and depression of patients, and can improve the long-term effect. The mechanism may be related to the increase of plasma MOT level and the decrease of serum GAS level.
【作者单位】：广西中医药大学附属瑞康医院;广西中医药大学;
【基金】：广西中医药民族医药传承创新专项(GZLC16-17) 广西中医药民族医药自筹经费科研项目(GZZC15-19)
【分类号】：R259

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