蛭龙活血通瘀胶囊治疗后循环缺血性眩晕的临床疗效观察

发布时间：2018-06-06 02:01

本文选题：后循环缺血 + 眩晕　；参考：《西南医科大学》2016年硕士论文

【摘要】：目的:观察蛭龙活血通瘀胶囊治疗后循环缺血性眩晕的有效性和安全性。方法:采用随机、对照试验研究,选择符合标准的病例共60例,随机分为观察组30例和对照组30例。西医诊断标准参照《中国后循环缺血的专家共识》及《实用神经病学》。中医诊断、中医分型标准参照《中医病证诊断疗效标准》中有关标准拟定。对照组给予盐酸氟桂利嗪胶囊10mg qd,观察组在对照组治疗基础上加用蛭龙活血通瘀胶囊4粒tid,7天为一个疗程,连续2个疗程。观察两组的临床疗效、中医临床症状积分、血液流变学、椎基底动脉平均血流速度(Vm)及椎基底动脉血管搏动指数(PI)的变化情况及药物安全性监测。结果:(1)治疗后蛭龙活血通瘀胶囊观察组总的临床有效率是93.33%,对照组总的临床有效率是75.56%,说明蛭龙活血通瘀胶囊观察组总的临床有效率明显优于对照组(P0.05);(2)治疗后蛭龙活血通瘀胶囊观察组在眩晕、恶心呕吐、耳鸣、跌倒、舌象几种症状上均有明显改善,对照组仅在眩晕、耳鸣、脉象三种症状上有改善,且蛭龙活血通瘀胶囊观察组在眩晕、耳鸣症状上的改善优于对照组,说明蛭龙活血通瘀胶囊观察组对眩晕等中医临床症状的改善明显优于对照组(P0.05);(3)治疗后蛭龙活血通瘀胶囊观察组除血浆粘度外其他指标均有所改善,对照组仅红细胞聚集指数与血沉有所改善,且蛭龙活血通瘀胶囊观察组较对照组改善更明显,说明蛭龙活血通瘀胶囊观察组可明显改善患者的血液流变学指标;(4)两组治疗后椎基底动脉血流速度(Vm)均有改善,但蛭龙活血通瘀胶囊观察组较对照组改善明显(P0.05),说明蛭龙活血通瘀胶囊观察组能有效改善椎基底动脉的供血情况;(5)治疗后蛭龙活血通瘀胶囊观察组能有效改善椎基底动脉血管搏动指数(PI),而对照组无改善,说明蛭龙活血通瘀胶囊观察组能降低血管的阻力,提高血管的弹性;(6)整个观察过程中未发现不良事件。结论:蛭龙活血通瘀胶囊治疗后循环缺血性眩晕在提高临床疗效、改善中医临床症状、改善血液流变学指标、改善后循环供血情况、提高血管弹性方面均有较好的疗效,且临床使用有较高安全性。
[Abstract]:Objective: To observe the efficacy and safety of budilon Huoxue Tongyu capsule in the treatment of postoperative circulatory ischemic vertigo. Methods: a randomized, controlled trial was used to select 60 cases of standard cases and randomly divided into observation group (30 cases) and control group (30 cases). The Western medical diagnostic criteria referred to the expert consensus > and < practical neurology > < practical neurology >. Chinese medicine diagnosis, traditional Chinese medicine classification standard refer to the standard of "TCM syndrome diagnosis curative effect standard > standard". The control group was given Flunarizine Hydrochloride Capsules 10mg QD, and the observation group was treated with leech Huoxue Tongyu capsule 4 TID, 7 days as a course and 2 continuous treatments. The clinical curative effect of the two groups was observed and the clinical symptom of TCM was accumulated. The changes of blood rheology, mean blood flow velocity of vertebrobasilar artery (Vm) and vascular pulsation index (PI) of vertebrobasilar artery (PI) were monitored. Results: (1) the total clinical effective rate of hirudon Huoxue Tongyu capsule observation group was 93.33%, and the total clinical effective rate of the control group was 75.56%, indicating the observation group of hirudon Huoxue Tongyu capsule The total clinical efficiency was obviously better than that of the control group (P0.05); (2) after the treatment, the observation group of vertigo, nausea and vomiting, tinnitus, tumble and tongue image were obviously improved in the observation group after treatment. The control group only improved on three symptoms of vertigo, tinnitus and pulse condition in the control group, and the change of the symptoms of vertigo and tinnitus in the observation group of leeudlong Huoxue Huoxue Tongyu capsule It was better than the control group, indicating that the improvement of the clinical symptoms of vertigo, such as vertigo, was obviously better than the control group (P0.05). (3) the other indexes in the observation group of the hirudon Huoxue Huoxue Tongyu capsule were improved, the erythrocyte aggregation index and erythrocyte sedimentation rate in the control group were improved, and the leeudun Huoxue Tongyu capsule The observation group improved more obviously than the control group, indicating that the blood rheology index of the patients was obviously improved by the hirudon Huoxue Tongyu capsule observation group. (4) the blood flow velocity (Vm) of the vertebral basilar artery in the two groups were improved, but the observation group of the hirudon Huoxue Tongyu capsule was more than that of the control group Gai Shanming (P0.05), indicating that the observation group of hirudon Huoxue Huoxue Tongyu capsule could have The blood supply of vertebrobasilar artery was improved; (5) after treatment, the bhirudon Huoxue Tongyu capsule observation group could effectively improve the vertebral basilar artery blood vessel pulsation index (PI), but the control group had no improvement, which indicated that the observation group of hirudon Huoxue Huoxue Tongyu capsule could reduce vascular resistance and increase the elasticity of blood vessels. (6) no adverse events were found during the whole observation process. Conclusion: The treatment of postoperative circulatory ischemic vertigo by leeilon Huoxue Tongyu capsule is effective in improving clinical curative effect, improving clinical symptoms, improving hemorrheology index, improving circulation of blood supply in the posterior circulation, improving blood vessel elasticity, and having high safety in clinical use.
【学位授予单位】：西南医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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