补肾活血中药复方治疗男性免疫性不育的系统评价

发布时间：2018-06-06 08:57

本文选题：补肾活血 + 男性免疫性不育　；参考：《中医药导报》2017年05期

【摘要】：目的:评价补肾活血中药复方治疗男性免疫性不育的疗效和安全性,为其在临床的应用提供循证医学的依据。方法:检索1995年1月至2015年12月补肾活血中药复方治疗男性免疫性不育的随机对照研究文献,运用Jadad量表评价纳入文献的方法学质量,用Rev Man5.3软件完成统计和系统评价。结果:共15篇文献包含1841例患者纳入本项研究。Meta分析结果显示,治疗组在提高患者配偶妊娠率以及提高患者抗精子抗体转阴率方面均优于对照组。结论:补肾活血中药治疗男性免疫性不育有较好的疗效,但由于现有试验的方法学质量普遍较低,目前尚无足够证据支持其治疗应用,需要更多高质量、大样本的随机对照试验评价其疗效和安全性。
[Abstract]:Objective: to evaluate the efficacy and safety of Bushen Huoxue compound in the treatment of male immune infertility and to provide evidence-based medicine for its clinical application. Methods: from January 1995 to December 2015, a randomized controlled study on the treatment of male immune infertility with Bushen Huoxue compound was searched. Jadad scale was used to evaluate the methodological quality of the literature included, and the statistical and systematic evaluation was completed with the software Rev Man5.3. Results: a total of 15 articles including 1841 patients were included in this study. Meta-analysis showed that the treatment group was superior to the control group in improving the pregnancy rate of spouses and the negative rate of anti-sperm antibody. Conclusion: Chinese medicine for tonifying kidney and activating blood circulation has a better curative effect on male immune infertility. However, because the methodological quality of current trials is generally low, there is not enough evidence to support its application, and more high quality is needed. The efficacy and safety of large-sample randomized controlled trials were evaluated.
【作者单位】：南京中医药大学;北京中医药大学;江苏建康职业学院;
【分类号】：R277.5

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