四通胶囊治疗下肢深静脉血栓形成的临床研究

发布时间：2018-06-06 21:16

本文选题：下肢深静脉血栓形成 + 四通胶囊　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:探讨四通胶囊治疗下肢深静脉血栓形成的疗效及机制。方法:按照入选标准,将纳入的60例患者随机分成两组,治疗组30例,对照组30例。两组均采用尿激酶、低分子肝素钙、丹参注射液及中药汤剂治疗。治疗组给予四通胶囊口服,对照组给予血塞通片口服。观察两组总疗效、中医证候总积分、肢体周径差、D-二聚体、纤维蛋白原的含量及静脉通畅率的变化。结果:治疗组的总有效率为90.00%,对照组的总有效率73.33%(P0.05)。治疗组及对照组中医证候总积分治疗后较治疗前均显著降低(P0.01),两组患者治疗后中医证候总积分治疗组低于对照组(P0.05);治疗组及对照组周径差治疗后较治疗前均显著降低(P0.01),两组患者治疗后周径差治疗组低于对照组(P0.05);治疗组及对照组D-二聚体含量治疗后第30天较治疗前均显著降低(P0.01),两组患者治疗后第15天、第30天D-二聚体含量治疗组低于对照组(P0.05);治疗组及对照组纤维蛋白原治疗后较治疗前均显著降低(P0.01),两组患者治疗后纤维蛋白原治疗组低于对照组(P0.05);治疗组及对照组静脉通畅总评分治疗后较治疗前均显著降低(P0.01),两组患者治疗后静脉通畅率治疗组高于对照组(P0.05)。结论:四通胶囊对下肢深静脉血栓形成患者有较好的疗效,能改善患肢肿痛等临床症状,促进静脉再通,而且临床无不良反应,可靠、安全,可以推广应用。
[Abstract]:Objective: to investigate the therapeutic effect and mechanism of Sitong capsule on deep venous thrombosis of lower extremity. Methods: according to the inclusion criteria, 60 patients were randomly divided into two groups: treatment group (n = 30) and control group (n = 30). Both groups were treated with urokinase, low molecular weight heparin calcium, salvia miltiorrhiza injection and traditional Chinese medicine decoction. The treatment group was treated with Sitong capsule and the control group with Xuesaitong tablet. The changes of total curative effect, total integral of TCM syndromes, D-dimer, fibrinogen content and patency rate of vein were observed. Results: the total effective rate was 90.00g in the treatment group and 73.33 in the control group. The total integral of TCM syndromes in the treatment group and control group was significantly lower than that before treatment, the total integral of TCM syndrome in the two groups was lower than that in the control group after treatment, and that in the treatment group and control group was significantly lower than that in the control group after treatment. After treatment, the dimer content in the treatment group and the control group was significantly lower than that in the control group on the 30th day after treatment, and at the 15th day after treatment, there was no significant difference between the two groups on the 15th day after treatment, and the concentration of D-dimer in the treatment group was significantly lower than that in the control group on the 30th day after treatment. On the 30th day, the content of D-dimer in the treatment group was lower than that in the control group (P 0.05A), the fibrinogen content in the treatment group and the control group was significantly lower than that before treatment, and the fibrinogen content in the treatment group was lower than that in the control group after treatment (P 0.05), and that in the treatment group and control group was lower than that in the control group. The total score of venous patency in the two groups was significantly lower than that before treatment, and the patency rate of the two groups was higher than that of the control group (P 0.05). Conclusion: Sitong capsule has better curative effect on patients with deep venous thrombosis of lower extremity, can improve clinical symptoms such as swelling and pain of affected limbs, promote vein recanalization, and it has no adverse reaction, is reliable, safe and can be popularized and applied.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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