瑶族药消瘤藤的化学成分分析

发布时间：2018-06-07 14:03

本文选题：瑶族药 + 消瘤藤　；参考：《中国实验方剂学杂志》2017年14期

【摘要】：目的:对瑶族药消瘤藤Pileostegia tomentella的化学成分进行研究,以期能对其化学成分进行初步的阐明,促进其深入开发与利用。方法:采用溶剂提取法、萃取法、硅胶柱色谱法、重结晶法等方法对消瘤藤95%乙醇提取物进行分离和纯化,采用红外光谱法、质谱法、核磁共振法等现代波谱学方法对分离得到的化合物进行结构分析测试并鉴定。结果:从消瘤藤的95%乙醇提取物中分离得到9个化合物,通过波谱学方法鉴定为二十四烷酸(1),蒲公英赛醇(2),β-谷甾醇(3),3β-乙酰氧基-乌苏酸(4),豆甾烷-3,6-二酮(5),7-羟基-8-甲氧基香豆素(6),茵芋苷(7),7-羟基香豆素(8),3,4-二羟基苯甲酸(9)。其中7-羟基-8-甲氧基香豆素(6),茵芋苷(7),7-羟基香豆素(8)3个化合物为香豆素类成分。结论:化合物1~9均为首次在该植物中分离得到,该植物中富含多种香豆素类成分。该研究一定程度上对消瘤藤的化学物质基础进行了揭示,也能促进其定性定量质控手段的建立。
[Abstract]:Objective: to study the chemical constituents of Pileostegia tomentella from Yao nationality in order to elucidate its chemical composition and promote its further development and utilization. Methods: 95% ethanol extract was isolated and purified by solvent extraction, silica gel column chromatography and recrystallization. The structures of the isolated compounds were analyzed and identified by NMR and other modern spectroscopic methods. Results: nine compounds were isolated from the 95% ethanol extract of Dioscorea sinensis. It was identified by spectroscopic method as 24 alkanoic acid, dandelion, 尾 -sitosterol, 尾 -sitosterol, 3 尾 -acetyloxy, ursolic acid, daistane, 7-hydroxy-8-methoxycoumarin, danjac, 7-hydroxycoumarin, 3-hydroxylcoumarin, 4-dihydroxybenzoic acid. Among them, 7- hydroxy-8-methoxy-coumarin (7-, 7-) -hydroxy-coumarin (7-hydroxy-8-coumarin) are coumarin compounds. Conclusion: compound 1 + 9 was isolated from this plant for the first time, and it is rich in many coumarins. To some extent, this study revealed the chemical substance basis of Astragalus sinensis, and also promoted the establishment of qualitative and quantitative quality control methods.
【作者单位】：广西壮族自治区中医药研究院;广西中药质量标准研究重点实验室;
【基金】：广西中药质量标准研究重点实验室系统性研究项目(桂中重系201404)
【分类号】：R29

【相似文献】