黄芪建中汤合身痛逐瘀汤加味治疗溃疡性结肠炎（气虚血瘀证）的临床观察

发布时间：2018-06-08 00:03

本文选题：溃疡性结肠炎 + 黄芪建中汤合身痛逐淤汤　；参考：《长春中医药大学》2016年硕士论文

【摘要】：目的:观察在虚瘀理论指导下,以温中补气,化瘀通络为治法,运用黄芪建中汤合身痛逐淤汤加味治疗气虚血瘀证溃疡性结肠炎的效果,并且观察评价中药复方的临床疗效及安全性,从而证明中医药整体观念、辩证施治的优越性,为进一步探究溃疡性结肠炎病因病机和指导临床提供了临床证据。方法:根据筛选标准找出符合气虚血瘀证的溃疡性结肠炎患者,随机分出观察组和对照组,分别30例患者,观察组给予身痛逐淤汤合黄芪建中汤加味中成药内服,早晚饭后分服,共4周的疗程,对照组给予美沙拉嗪肠溶片口服,每次2片,每日3次,总共治疗4周。对比观察疗效。结果:经统计学处理,对照组和观察组治疗前的一般情况、治疗前的症状积分和肠镜积分没有差别,治疗后差异均有统计学意义(P0.05),观察组疗效优于对照组(1)观察组30例中,治疗前症状得分为28.64±4.79;对照组30例中治疗前症状得分为28.60±4.94。观察组30例中,治疗后症状得分为8.37±3.65;对照组30例中治疗后症状得分为14.39±3.68,观察组的症状改善优于对照组。(2)观察组30例中,治疗前肠镜积分16.79±7.54;对照组30例中治疗前肠镜积分16.90±5.67。观察组30例中,治疗后肠镜积分7.44±5.33;对照组30例中治疗后肠镜积分11.89±0.98。观察组治疗后肠镜愈合优于对照组。(3)观察组30例中,临床治愈、显效、有效、无效分别为9例、13例、9例、0例,总有效率为98.01%;对照组30例中,临床治愈、显效、有效、无效分别为4例,10例,17例,0例,总有效率为80.43%,观察组的综合疗效优于对照组。(4)观察组30例中,肠粘膜疗效显效、有效、无效分别为10例、20例、0例,总有效率为90.01%;对照组30例中,临床有效、无效分别为8例,17例,5例,总有效率为78.43%,观察组的肠粘膜优愈合于对照组。结论:由以上统计结果显示本实验虚瘀理论的可靠性,进一步验证了中药复方的临床效果,通过同步观察此实验的患者不良反应,证明了实验的安全性,进一步完善了中医药治疗溃疡性结肠炎的理论,为以后临床治疗溃疡性结肠炎提供了有力的参考。
[Abstract]:Objective: to observe the effect of Huangqi Jianzhong decoction on treating ulcerative colitis of qi deficiency and blood stasis syndrome with Huangqi Jianzhong decoction in accordance with the theory of deficiency of blood stasis and the treatment of ulcerative colitis with warming and supplementing qi, removing blood stasis and removing blood stasis, and using Huangqi Jianzhong decoction to treat ulcerative colitis of Qi deficiency and blood stasis syndrome. Observation and evaluation of the clinical efficacy and safety of traditional Chinese medicine compound, so as to prove the overall concept of traditional Chinese medicine, the superiority of dialectical treatment, for further explore the etiology and pathogenesis of ulcerative colitis and provide clinical evidence for clinical guidance. Methods: according to the screening criteria, the patients with ulcerative colitis with Qi deficiency and blood stasis syndrome were randomly divided into observation group (n = 30) and control group (n = 30). The control group was treated with mesalazine enteric-coated tablets 3 times a day for 4 weeks. The curative effect was compared and observed. Results: after statistical analysis, there was no difference between control group and observation group in the general situation before treatment, symptom score and enteroscopy score before treatment. The difference after treatment was statistically significant (P 0.05). The curative effect of observation group was better than that of control group (n = 30). The score of symptoms before treatment was 28.64 卤4.79, and that of control group was 28.60 卤4.94. The symptom score after treatment was 8.37 卤3.65 in the observation group and 14.39 卤3.68 in the control group. The improvement of symptoms in the observation group was better than that in the control group (16.79 卤7.54) in the observation group, 16.90 卤5.67 in the control group. In the observation group (30 cases), the postoperative enteroscopy score was 7.44 卤5.33, while in the control group (11.89 卤0.98). In the observation group (30 cases), the clinical cure, remarkable effect, effective and ineffective were 9 cases, 13 cases and 9 cases, respectively. The total effective rate was 98.01. In the control group, 30 cases were cured, obviously effective and effective. The total effective rate was 80.43. The comprehensive curative effect of observation group was better than that of control group. In 30 cases of observation group, the curative effect of intestinal mucosa was remarkable and effective, and the total effective rate was 90.01 in 10 cases and 20 cases, respectively, and the total effective rate was 90.01in the control group, 30 cases in the control group, and 30 cases in the control group. The clinical effective, ineffective were 8 cases and 17 cases, respectively, and the total effective rate was 78.43. The intestinal mucosa of the observation group was better healed than that of the control group. Conclusion: the above statistical results show the reliability of the theory of deficiency and stasis in this experiment, and further verify the clinical effect of traditional Chinese medicine compound. The safety of the experiment is proved by observing the adverse reactions of the patients in this experiment simultaneously. Further improve the theory of Chinese medicine treatment of ulcerative colitis, for the future clinical treatment of ulcerative colitis to provide a strong reference.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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