化痰解郁方治疗轻中度抑郁症发作期（痰热上扰证）的临床研究

发布时间：2018-06-08 13:38

本文选题：抑郁症 + 化痰解郁方　；参考：《成都中医药大学》2016年硕士论文

【摘要】：目的：通过临床观察,验证化痰解郁方治疗轻中度抑郁症发作期(痰热上扰证)的临床疗效及安全性。方法：采用CCMD-3版抑郁发作的诊断标准确定抑郁的存在,并采用中医证候标准进行辨证分型,病例选自2015年09月至2016年2月成都中医药大学附属医院神经内科门诊的符合要求的患者63例,用数字随机表随机、对照试验的方法,分为试验组(中药组)、对照组(西药组),两组比例为2：1,即试验组42例、对照组21例,实验中脱落4例,治疗方法：试验组给予化痰解郁方口服,每天三次,每次200ml；对照组给予百优解口服,每天一次,每次20mg,疗程8周,分别在用药前、用药2周、4周、6周、8周后对各组进行评估,包括中医症状的观察和HAMD等量表评分情况。在用药前及用药8周后进行安全性指标的观测以评定药物安全性。结果：①疗效评价：对于轻中度抑郁症(痰热上扰证)患者,试验组：有效32例,无效7例,总有效率为82.1%；治疗组：有效17例,无效3例,总有效率为85%。试验组治疗后与治疗前比较有很好的疗效(P=0.000),对照组治疗后与治疗前比较有很好的疗效(P=0.000),但两组疗效之间无明显差异(P=0.775)。②抑郁相关因子的改善评价,两组相比,试验组在改善胃肠道症状、睡眠障碍症状方面均有明显的优势(P0.05)。③中医证候的改善评价,试验组：有效35例,无效4例,总有效率为89.7%；治疗组：有效11例,无效9例,总有效率为55%。两组疗效之间有明显差异(P=0.020),试验组在中医症候的改善上优于对照组。④安全性观察：试验组和对照组不良反应发生率之间有差异(P=0.041),试验组不良反应发生率低于对照组。结论：化痰解郁方对轻中度抑郁症(痰热上扰证)患者有明显的疗效,而且无明显的不良反应。
[Abstract]:Objective: to verify the clinical efficacy and safety of Huatan Jieyu prescription (Huatan Jieyu decoction) in the treatment of mild and moderate depression. Methods: the existence of depression was determined by the diagnostic criteria of CCMD-3 version of depression, and the syndrome differentiation criteria of traditional Chinese medicine (TCM) were used. From September 2015 to February 2016, 63 patients in the Department of Neurology, affiliated Hospital of Chengdu University of traditional Chinese Medicine, were selected. The experimental group was divided into two groups: the traditional Chinese medicine group and the control group. The ratio of the two groups was 2: 1, that is, 42 cases in the experimental group and 21 cases in the control group. The treatment methods were as follows: the experimental group was given Huatan Jieyu decoction three times a day. The control group was given Baiyou Jie orally, once a day, 20 mg every time, for 8 weeks. Before and after 2 weeks and 4 weeks and 6 weeks and 8 weeks, the control group was evaluated, including the observation of TCM symptoms and Hamd score. Safety indexes were observed before and 8 weeks after administration to evaluate drug safety. Results: for patients with mild and moderate depression (phlegm heat disturbance), 32 cases were effective, 7 cases were ineffective, and the total effective rate was 82.1, in the treatment group, 17 cases were effective, 3 cases were ineffective, and the total effective rate was 85.1%. There was a good effect after treatment in the trial group and 0.000 in the control group. However, there was no significant difference between the two groups in the improvement of depression related factors, and there was no significant difference between the two groups in the improvement of the depression related factors, and there was no significant difference between the two groups. In the trial group, there were obvious advantages in improving gastrointestinal symptoms and sleeping disorder symptoms. In the trial group, 35 cases were effective, 4 cases were ineffective, the total effective rate was 89.7; in the treatment group, 11 cases were effective and 9 cases were ineffective. The total effective rate is 55. There was significant difference between the two groups in curative effect. The improvement of TCM symptoms in the trial group was better than that in the control group. The safety observation showed that there was a difference in the incidence of adverse reactions between the experimental group and the control group, and the incidence of adverse reactions in the experimental group was lower than that in the control group. Conclusion: Huatan Jieyu prescription has obvious curative effect on mild and moderate depression (phlegm heat disturbance syndrome), and has no obvious adverse reaction.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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