老年不稳定型心绞痛证素及益心舒对其疗效的临床研究

发布时间：2018-06-13 00:36

本文选题：益心舒胶囊 + 老年不稳定型心绞痛　；参考：《南京中医药大学》2016年硕士论文

【摘要】：目的：探讨“老年不稳定型心绞痛证素及益心舒对其疗效的临床研究”,运用证素辨证学探讨其证素特点,为中医药规范化治疗提供参考。方法：将纳入的符合研究标准的86例患者,随机分为治疗组和对照组,治疗组44例,对照组42例。对照组给予常规治疗,治疗组在常规治疗的基础上加服益心舒胶囊,3粒／次,3次/日,疗程为2周。观察治疗组和对照组的心绞痛症状、中医证候、心电图的改善情况,硝酸甘油、速效救心丸用量的变化情况及证素分析。结果：1.心绞痛疗效方面：治疗组总有效率为84.0%,对照组总有效率为76.1%,差异无统计学意义(P0.05)。2.心电图疗效方面：治疗组心电图好转率为55.5%,对照组心电图好转率为47.6%,差异无统计学意(P0.05)。3.硝酸甘油等抗心绞痛药物停减率方面：治疗组为72.7%,对照组为66.6%,差异无统计学意义(P0.05)。4.中医证候疗效方面：治疗组的总有效率为86.3%,对照组的总有效率为66.6%,差异具统计学意义这(P0.05)。5.证素分析结果：临床诊断89.1%符合证素辨证学的规范证名,单一证素的贡献度为心系证素气虚证素阴虚证素,症候辨证素量表症状频数贡献度的分布,基本符合高龄不稳定型心绞痛(气阴两虚证)患者的临床表现。结论：1.西医常规治疗联合益心舒胶囊治疗,在冠心病不稳定型心绞痛患者的心绞痛疗效、心电图变化、硝酸甘油及速效救心丸减停率方面,与西医常规治疗无明显差异。2.西医常规治疗联合益心舒胶囊治疗,在中医疗效方面优于单用西医常规治疗。3.证素分析结果提示老年不稳定型心绞痛(气阴两虚证)常见症候为胸闷、心痛及胸痛,单一证素的贡献度为心系证素气虚证素阴虚证素,为临床气阴两虚证的准确诊断提供了参考依据。
[Abstract]:Objective: to explore the clinical study on the therapeutic effect of senile unstable angina pectoris syndrome and Yixinshu syndrome, and to explore the characteristics of syndrome element by syndrome differentiation, and to provide reference for the standardized treatment of traditional Chinese medicine. Methods: 86 patients were randomly divided into treatment group (n = 44) and control group (n = 42). The control group was treated with routine therapy, the treatment group was treated with 3 capsules of Yixinshu capsule 3 times a day, the course of treatment was 2 weeks. The symptoms of angina pectoris, TCM syndromes, improvement of electrocardiogram, nitroglycerin, dosage of Quick-acting Jiuxin pills and syndromes were observed in the treatment group and the control group. The result is 1: 1. The total effective rate of angina pectoris was 84.0 in the treatment group and 76.1in the control group. The improvement rate of electrocardiogram in the treatment group was 55.5, and the improvement rate in the control group was 47.6. The difference was not significant (P 0.05). The stopping rate of anti-angina pectoris drugs such as nitroglycerin was 72.7 in the treatment group and 66.6 in the control group, the difference was not statistically significant (P 0.05). The curative effect of TCM syndrome: the total effective rate of the treatment group was 86.3, the total effective rate of the control group was 66.6, the difference was statistically significant (P 0.05). The results of analysis of syndromes were as follows: the clinical diagnosis was in accordance with the standard syndromes of syndrome differentiation, and the contribution of single syndrome factors was the distribution of symptom frequency of syndrome differentiation scale, the contribution degree of single syndromes was the element of yin deficiency of syndrome factors of heart system syndrome, and the distribution of symptom frequency of syndrome differentiation factor scale. Basically accord with the clinical manifestation of senile unstable angina pectoris (qi and yin deficiency syndrome). Conclusion 1. Western medicine combined with Yixinshu capsule in patients with coronary heart disease unstable angina pectoris curative effect, electrocardiogram changes, nitroglycerin and fast Jiuxin pills to reduce stop rate, there is no significant difference between the routine treatment of Western medicine. 2. Western medicine routine treatment combined with Yixinshu capsule treatment, in traditional Chinese medicine curative effect is superior to using western medicine routine treatment. 3. 3. The results of syndrome element analysis indicated that the common symptoms of senile unstable angina pectoris (qi and yin deficiency syndrome) were chest tightness, heart pain and chest pain, and the contribution degree of single syndrome element was that of heart system syndrome, qi deficiency syndrome and yin deficiency syndrome. It provides a reference for the accurate diagnosis of Qi and Yin deficiency syndrome.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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