当归地黄饮加减治疗肾阴虚型经间期出血的临床观察

发布时间：2018-06-13 08:00

本文选题：当归地黄饮 + 经间期出血　；参考：《长春中医药大学》2016年硕士论文

【摘要】：目的:通过对当归地黄饮加减治疗肾阴虚型经间期出血的临床资料进行分析,从而为当归地黄饮加减治疗本病的临床推广应用提供科学依据。方法:本研究在长春中医药大学的妇科门诊开展,使用随机、药物平行对照设计方法,将符合纳入病例标准的72例患者平均分成治疗组和对照组。治疗组给予当归地黄饮加减,于月经周期第7天开始连服10剂,日1剂,中药免煎颗粒,药液混合,早晚各1次;对照组给予九芝堂六味地黄丸口服,与治疗组相同时间开始连服10天,一次12丸,早晚各1次。每用药1个月经周期后进行症状积分评定和疗效评价,观察止血效果和治疗前后的症状积分的变化,综合以上分析结果,评估当归地黄饮加减的临床应用意义。结果:(1)治疗组的临床疗效总有效率优于对照组。(2)治疗组止血效果优于对照组。(3)治疗后两组中医临床症状积分均较前明显下降,差异具有显著统计学意义(P0.01);且治疗后治疗组缓解症状效果优于对照组。(4)治疗后治疗组腰膝酸软、头晕耳鸣、五心烦热、夜寐不宁的患者例数明显减少或症状明显减轻,差异具有统计学意义(P0.05);而大便干燥、小便短黄的患者例数或病情程度无较大变化,差异无统计学意义(P0.05)。(5)两组在治疗过程中未出现与药物有关的不良反应。由此可见,当归地黄饮加减用于肾阴虚型经间期出血的治疗效果明显优于对照组。结论:当归地黄饮加减治疗组与九芝堂六味地黄丸对照组治疗肾阴虚型经间期出血,治疗组在总疗效、止血效果的比较上优于对照组。由此得出,当归地黄饮加减治疗经间期出血肾阴虚证安全、有效,可明显改善患者临床症状和出血情况,降低中医临床症状总积分,改善肾阴虚导致伴随症状,说明本方具有良好的止血效果,疗效确切,未见不良反应与其他副作用,有在临床上广泛应用的可行性和实践意义。
[Abstract]:Objective: to analyze the clinical data of the treatment of interphase hemorrhage of kidney yin deficiency type by adding and subtracting Angelica Dihuang decoction, so as to provide a scientific basis for the clinical popularization and application of the addition and subtraction of Angelica Dihuang decoction for the treatment of this disease. Methods: the study was carried out in the department of gynecology of Changchun University of traditional Chinese Medicine. The 72 patients who met the criteria were divided into two groups: treatment group and control group. The treatment group was given the addition and subtraction of Danggui Dihuang decoction, and on the 7th day of menstrual cycle, the treatment group began to take 10 doses, one dose per day, and the traditional Chinese medicine without decoction granules and liquid mixture, one time in the morning and evening, while the control group was given Jiuzitang Liuwei Dihuang pills orally. The same time as the treatment group began to take 10 days, 12 pills once, 1 in the morning and evening. After one menstrual cycle, the symptom score and curative effect were evaluated, the effect of hemostasis and the change of symptom score before and after treatment were observed, and the clinical application significance of the addition and subtraction of Danggui Dihuang decoction was evaluated by synthesizing the above analysis results. Results the total effective rate of the treatment group was better than that of the control group. (2) the hemostatic effect of the treatment group was better than that of the control group. The difference was statistically significant (P 0.01), and the effect of relieving symptoms in the treatment group was better than that in the control group. (4) after treatment, the patients in the treatment group were obviously reduced in the number of patients with sore waist and knee, dizziness and tinnitus, five-upset heat, restless sleep, or symptoms. The difference was statistically significant (P 0.05), but there was no significant change in the number of patients with dry stool and short yellow urine (P 0.05). It can be seen that the effect of the addition and subtraction of Danggui Dihuang decoction in the treatment of intermenstrual hemorrhage of kidney yin deficiency type is better than that of the control group. Conclusion: Danggui Dihuang decoction plus and subtraction treatment group and Jiuzitang Liuwei Dihuang pill control group in the treatment of kidney yin deficiency type of intermenstrual hemorrhage, the treatment group in the total efficacy, hemostatic effect is better than the control group. It is concluded that it is safe and effective to treat the syndrome of deficiency of kidney yin in the treatment of intermenstrual hemorrhage with Dihuang decoction, which can obviously improve the clinical symptoms and bleeding of patients, reduce the total score of clinical symptoms of traditional Chinese medicine, and improve the accompanying symptoms caused by deficiency of kidney yin. The results showed that the prescription had good hemostatic effect, no adverse reactions and other side effects, and had the feasibility and practical significance of wide application in clinical practice.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.11

【参考文献】