清气化痰丸联合雾化吸入治疗痰瘀互结型慢性阻塞性肺疾病的临床观察

发布时间：2018-06-14 12:36

本文选题：清气化痰丸 + 雾化　；参考：《中药药理与临床》2017年02期

【摘要】：目的:研究清气化痰丸联合雾化吸入治疗痰淤互结型慢性阻塞性肺疾病的临床疗效。方法:以我院呼吸科2015年1月~2016年7月期间诊断为痰淤互结型慢性阻塞性肺疾病的100例患者为资料纳入研究。抽签法分为2组,各50例。一组为对照组,给予异丙托溴铵雾化治疗,另一组为观察组,雾化基础上给予清气化痰丸治疗。分析两组在治疗后的疗效,治疗期间肺功能、血气以及炎症的改变情况。结果:在总体治疗效果上,观察组为94.00%,明显高于对照组78.00%。治疗后两组患者肺功能均较治疗前改善。观察组一秒钟用力呼气容积(FEVl)占预计值百分比(FEV1%预计值)和FEV1与用力肺活量(FVC)比值百分比分别为(60.04±2.57、66.85±3.25)%,均明显高于对照组(54.93±2.20、58.48±2.99)%。治疗后两组患者血气指标均较治疗前改善。观察组二氧化碳分压(PaCO_2)和氧分压(PaO_2)值分别为(39.45±2.86、75.48±3.26)mm Hg,均明显优于对照组(45.01±3.01、68.91±3.19)mm Hg。(4)治疗后两组患者炎症指标均较治疗前下降。观察组白细胞(WBC)、降钙素原(PCT)和白细胞介素-8(IL-8)水平分别为(6.03±0.49×109/L、0.68±0.24ng/ml、10.06±2.37pg/ml),均明显低于对照组(8.18±0.53×109/L、1.09±0.30ng/ml、16.02±2.51pg/ml)。结论:在雾化治疗的基础联合清气化痰丸能更有效的治疗痰淤互结型慢性阻塞性肺疾病,更明显的改善患者肺功能及下调其炎症因子水平。
[Abstract]:Objective: to study the clinical effect of Qingqi Huatan Pill combined with atomization inhalation in the treatment of chronic obstructive pulmonary disease. Methods: from January 2015 to July 2016, 100 patients with chronic obstructive pulmonary disease (COPD) with phlegm and stasis were included in the study. The drawing of lots was divided into two groups, 50 cases each. One group was treated with ipratropium bromide atomization and the other group was treated with Qingqi Huatan pill on the basis of atomization. The changes of lung function, blood gas and inflammation during treatment were analyzed. Results: the total therapeutic effect in the observation group was 94.00, which was significantly higher than that in the control group. After treatment, pulmonary function was improved in both groups. The percentage of FEV1 / FEV1) and the ratio of FEV1 to forced vital capacity in the observation group were 60.04 卤2.57V 66.85 卤3.25, respectively, which were significantly higher than those in the control group (54.93 卤2.2058.48 卤2.99g). After treatment, the blood gas indexes in both groups were improved compared with those before treatment. The values of Paco _ 2 and Paco _ 2 in the observation group were 39.45 卤2.86 卤75.48 卤3.26)mm Hg, respectively, which were significantly better than those in the control group (45.01 卤3.01 卤68.91 卤3.19)mm Hg.Hg). The levels of WBCU, PCT and IL-8 in the observation group were 6.03 卤0.49 脳 10 9 / L 0.68 卤0.24 ng / ml respectively, which were significantly lower than those in the control group (8.18 卤0.53 脳 10 9 / L 1.09 卤0.30 ng / ml) and 16.02 卤2.51pg / ml / ml respectively. Conclusion: combined with Qingqi Huatan Pill on the basis of atomization therapy can be more effective in the treatment of chronic obstructive pulmonary disease with phlegm and stasis, improve pulmonary function and down-regulate the level of inflammatory factors.
【作者单位】：东营市东营区人民医院;东营市东营区新区医院;
【基金】：2015年度山东省自然科学基金培养基金项目(2015ZRA05003)
【分类号】：R259

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