疏肝法对肝郁型MCI患者认知功能、尿8-OHdG及血浆SOD和LPO的影响

发布时间：2018-06-14 13:33

本文选题：疏肝法 + 肝气郁结　；参考：《中国中医基础医学杂志》2017年08期

【摘要】：目的:探讨疏肝法对肝郁型MCI患者肝郁程度、认知功能、尿8-OHdG及血浆SOD和LPO的影响。方法:用国际MCI诊断标准和肝气郁结证症状筛选标准筛选40~65岁的肝郁型MCI患者,用肝气郁结证症状程度计分表对患者的肝气郁结程度进行评测,用MoCA量表和WAIS-RC量表简式对患者的认知功能进行评测,用ELISA法对患者用药前后的尿8-OHdG、血浆SOD和LPO进行检测。结果:与用药前比较,患者用药后肝气郁结证症状程度计分降低;MoCA量表的视空间与执行、注意、语言、抽象、延迟回忆、定向及总分均升高,命名得分无明显改变;WAIS-RC量表四合一简式的相似性、数字广度、填图、木块图和总分升高;8-OHdG含量降低,SOD及LPO值无明显变化。结论:疏肝法能降低肝郁型MCI患者的肝气郁结症状,改善患者的认知功能,降低DNA的氧化损伤是认知功能改善的可能原因。
[Abstract]:Objective: to investigate the effects of soothing the liver method on the degree of liver depression, cognitive function, urine 8-OHdG and plasma SOD and LPO in patients with MCI with liver depression. Methods: according to the international MCI diagnostic criteria and the screening criteria for the symptoms of liver qi stagnation syndrome, the patients with liver depression type MCI aged 40 to 65 years old were selected, and the degree of stagnation of liver qi was evaluated by the score table of the symptoms of liver qi stagnation syndrome. The cognitive function of patients was evaluated with MoCA scale and WAIS-RC scale, and the urine 8-OHdG, plasma SOD and LPO were detected by Elisa. Results: compared with before treatment, the score of symptom degree of liver qi stagnation syndrome decreased the visual space and execution, attention, language, abstraction, delayed recall, orientation and total score of MoCA scale. The nomenclature score did not change obviously the similarity of the four-in-one simple formula of WAIS-RC scale, the number span, mapping, block map and total score increase, the content of 8-OHdG decreased the SOD and LPO value. Conclusion: the method of soothing the liver can reduce the symptoms of stagnation of liver-qi, improve the cognitive function and reduce the oxidative damage of DNA, which is the possible reason for the improvement of cognitive function.
【作者单位】：河南中医药大学;
【基金】：国家自然科学基金资助项目(81173148)-基于肝疏泄理论探讨情志对衰老进程中认知功能的影响及机制;国家自然科学基金资助项目(81473556)-疏肝法对情绪调节不良MCI患者工作记忆影响的机制研究河南中医药大学博士科研基金项目(BSJJ2011-08)-孔圣枕中丹对MCI患者认知功能和ERP成分的影响
【分类号】：R277.7

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