黄术合剂合亚甲蓝注射对湿热下注型肛门瘙痒的临床研究

发布时间：2018-06-14 18:26

本文选题：黄术合剂 + 亚甲蓝　；参考：《福建中医药大学》2016年硕士论文

【摘要】：目的：观察黄术合剂配合肛周亚甲蓝注射对湿热下注型肛门瘙痒症临床疗效。方法：将2015年2月～2016年1月符合纳入标准的60例肛门瘙痒症患者通过简单随机分组分为治疗组、对照组各30例,两组病例术前、术后均采用相同的基础治疗,治疗组术后予口服黄术合剂；术后第10天、2个月分别观察记录两组患者肛门瘙痒、潮湿、疼痛、皮损症状。结果：完成研究的病例共60例,对照组(N=30)和治疗组(N=30)。治疗前对两组病例的性别、年龄、病程及治疗前一般情况比较、瘙痒潮湿疼痛皮损面积的各项积分比较评分等进行比较,差异均无统计学意义,具有可比性。研究结果如下：(1)两组治疗前和术后第10天在瘙痒、潮湿、疼痛及皮损面积项积分的比较,及两组治疗前和术后2个月在瘙痒、潮湿、疼痛及皮损面积项积分的比较,两组在术后第10天及术后2个月各项积分均少于治疗前各项积分,说明在近期疗效和远期疗效中治疗组和对照组均能改善瘙痒、潮湿、疼痛、皮损面积；(2)两组在术后第10天(近期疗效)疼痛项积分的比较及两组术后2个月(远期疗效)疼痛项积分的比较,经秩和检验,两组在术后第10天及术后2个月疼痛项积分P均0.05,差异无统计学意义；说明在近期疗效和远期疗效中治疗组在减少搔抓后而引起的肛门疼痛的积分方面疗效未见明显优于对照组；(3)两组在术后第10天(近期疗效)瘙痒、潮湿及皮损面积项积分的比较及术后2个月(远期疗效)瘙痒、潮湿及皮损面积项积分的比较,经秩和检验,两组在术后第10天及术后2个月瘙痒、潮湿、皮损面积项积分P均0.05,说明治疗组在近期疗效和远期疗效中减少肛门瘙痒、潮湿、皮损面积积分方面疗效明显优于对照组,即治疗组在减轻肛门瘙痒、潮湿症状及恢复皮损的疗效方面优于对照组。(4)两组手术后第10天和术后2个月的总体疗效比较,P均0.05,均有统计学意义,说明在近期疗效和远期疗效中治疗组总体疗效均明显优于对照组；治疗组近期总有效率83.33%,对照组76.67%,治疗组远期总有效率83.33%,对照组73.33%,用统计学方法处理,两组总疗效比较有显著性差异(P0.05)；两组间症状疗效比较,在治疗肛门瘙痒方面存在显著性差异(P0.05),治疗组优于对照组。结论：黄术合剂具有清热利湿止痒之功,黄术合剂配合肛周亚甲蓝注射能明显改善肛门瘙痒症的瘙痒、潮湿症状,对湿热下注型肛门瘙痒症有良好的治疗作用。
[Abstract]:Objective: to observe the clinical effect of Huangzhu mixture combined with perianal methylene blue injection in treating anal pruritus with damp-heat injection. Methods: from February 2015 to January 2016, 60 patients with anal pruritus were randomly divided into treatment group (n = 30) and control group (n = 30). The patients in both groups were treated with the same basic treatment before and after operation. The patients in the treatment group were treated with Huangzhu mixture 10 days and 2 months after operation, and the symptoms of anal itching, damp, pain and skin lesions were observed and recorded in the two groups. Results: 60 cases (control group) and treatment group (n = 30) completed the study. Before treatment, the gender, age, course of disease and general situation before treatment were compared between the two groups, and the scores of each score of skin area of pruritus and moist pain were compared. The differences were not statistically significant and comparable. The results were as follows: (1) the scores of pruritus, humidity, pain and area of skin lesions were compared between the two groups before and 10 days after treatment, and the scores of itching, damp, pain and area of skin lesions were compared between the two groups before and 2 months after treatment. The scores of both groups on the 10th day after operation and 2 months after operation were less than those before treatment, which indicated that both the treatment group and the control group could improve the area of pruritus, damp, pain and skin lesion in the short-term and long-term curative effect. (2) the scores of pain items in the two groups were compared on the 10th day after operation (short-term curative effect) and 2 months after operation (long-term curative effect), the scores of pain items were compared by rank sum test. There was no significant difference in pain score between the two groups (P < 0.05) on the 10th day after operation and 2 months after operation. The results showed that the curative effect of the treatment group was not significantly better than that of the control group in reducing the score of anal pain caused by scratching in the short and long term.) the pruritus of the treatment group was not significantly better than that of the control group on the 10th day after operation (short-term curative effect). The comparison of the score of wet area and skin lesion area and the score of itching at 2 months after operation, the score of wet area and area of skin lesion were compared by rank sum test, the two groups had itching and damp on the 10th day after operation and 2 months after operation. The score of the area of skin lesion was 0.05, which indicated that the treatment group was superior to the control group in reducing anal pruritus and damp in the short-term and long-term curative effect, that is, the treatment group was better than the control group in reducing the anal itching. The effect of wet symptoms and recovery of skin lesions was better than that of control group (P < 0.05), 10 days after operation and 2 months after operation. The results showed that the overall curative effect of the treatment group was obviously better than that of the control group in both the short-term and the long-term curative effect, the total effective rate in the treatment group was 83.33, the control group was 76.67, the total long-term effective rate in the treatment group was 83.33, the control group was 73.33, and the statistical method was used. There was significant difference in the total curative effect between the two groups (P 0.05), and there was significant difference in the treatment of anal pruritus between the two groups (P 0.05), and the treatment group was superior to the control group. Conclusion: Huangzhu mixture has the function of clearing heat, promoting dampness and stopping itching. Huangzhu mixture combined with perianal methylene blue injection can obviously improve the pruritus and damp symptoms of anal pruritus, and has a good therapeutic effect on the anal pruritus caused by damp-heat injection.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

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