非糜烂性反流病中医证候学特点调查研究

发布时间：2018-06-16 23:30

本文选题：非糜烂性反流病 + 统计学方法　；参考：《北京中医药大学》2017年硕士论文

【摘要】：研究意义和目的:中医在辨证治疗非糜烂性反流病具有独特的优势,而辨证治疗的关键是对证候学有明确的认识,因此对本病的证候学研究就显得至关重要了。本课题在中医理论知识的指导下,通过对本病的文献研究、流行病学及证候学调查,运用多元统计学的方法对本病的证型及证候要素分布特征进行探讨,并分析了本病可能的病因病机,为本病的辨证论治及科研提供参考依据。研究方法:本研究将所收集277例非糜烂性反流病患者的数据资料(包括一般资料、中医证候信息)录入Excel表格,建立数据库,使用SPSS21.0软件进行统计分析;一般资料、疾病危险因素采用描述统计及描述推断;中医证候信息采用多元统计学方法,以研究本病常见的证候分布特征及病因病机。研究结果:1、一般资料结果:本次调查研究共收集277例NERD患者一般资料与四诊信息,其中年龄最小者19岁,年龄最大者75岁,平均年龄48.49±13.134岁,中位年龄为51岁;男性93例,女性184例。对所收集数据进行统计分析:①发病年龄段特点:以青年组及中年组发病率最高,分别占38%和39%;②发病性别特点:女性发病率高于男性,男女比例为0.51:1,其中中老年女性发病率明显高于男性;③发病体重特点:以体重正常者居多,约占55%;④发病职业特点:离退休及无业者偏多(44%),其次分别为行政及管理人员、商业及服务业、私营及个体工商,发病率分别为17%、15%和14%;⑤发病饮食特点:以油腻高脂肪(26%)、浓茶(14%)、辛辣(13%)等食物居多;⑥发病精神心理状态特点:异常心理状态患者比例占76%,其中,急躁易怒出现频率最高,占38.63%;⑦发病季节特点:以春季(37%)为主;⑧发病与HP感染:HP感染阳性的阳性率为82%。2、在中医证候方面:①主要症状:以反酸(91%)和烧心(84%)为主;②病位:主要在肝与胃,与脾、心、肺、胆等有一定的相关性;③病性:有虚实之分,虚者可见到气虚、阳虚,实证者可见到痰浊、食积、湿热、瘀血;④证型分布:可将本病大致分为五型:类湿热内蕴证、类痰瘀内阻证、类肝胃郁热证、类脾胃虚寒证、类肝胃不和证。研究结论:1、NERD患者以中青年为主;女性发病高于男性;发病与情绪、季节、HP感染等因素有关,与体重、饮食规律、睡眠质量未观察到明确相关性;2、中医证候方面:NERD患者以反酸、烧心为主要症状;病位:本病的主要病位证素在肝与胃,与脾、心、肺、胆等有一定的相关性;病性:有虚实之分,虚者可见到气虚、阳虚;实证者可见到痰浊、食积、湿热、瘀血;证型分布:可将本病大致分为五型:类湿热内蕴证、类痰瘀内阻证、类肝胃郁热证、类脾胃虚寒证、类肝胃不和证。
[Abstract]:Research significance and objective: TCM has a unique advantage in the treatment of non-erosive reflux disease, and the key of dialectical treatment is to have a clear understanding of syndromes, so it is very important to study the syndromes of this disease. Under the guidance of traditional Chinese medicine theory knowledge, through the literature research, epidemiology and syndromes investigation of the disease, using the method of multivariate statistics to discuss the distribution characteristics of syndrome types and syndromes elements of the disease. The possible etiology and pathogenesis of this disease are analyzed to provide reference for syndrome differentiation and scientific research. Methods: the data of 277 patients with non-erosive reflux disease (including general information, TCM syndrome information) were recorded in Excel form, database was established, and SPSS21.0 software was used for statistical analysis. The disease risk factors were described and inferred, and the information of TCM syndromes were analyzed by multivariate statistical method to study the characteristics of syndromes distribution, etiology and pathogenesis of the disease. Results: in this study, we collected information of 277 NERD patients. The youngest was 19 years old, the oldest was 75 years old, the average age was 48.49 卤13.134 years, the median age was 51 years old. 184 women. Statistical analysis of the collected data showed that the incidence rate in the youth group and middle age group was the highest, accounting for 38% and 39%, respectively. The incidence rate of female was higher than that of male. The male / female ratio was 0.51: 1, of which the incidence rate of elderly women was significantly higher than that of males. Most of them were of normal weight, accounting for about 55 / 4 of the occupational characteristics of the disease. The number of retired and unemployed persons was 44%, followed by administrative and managerial staff, respectively. In business and service industry, private and individual business, the incidence rate was 17% and 14%, respectively. The most common dietary characteristics were fatty and fatty food (26%), thick tea (14%), spicy tea (13%) and so on. (6) characteristics of psychosomatic state: the proportion of patients with abnormal mental state accounted for 76g. Among them, the frequency of irritability and irritability was the highest, accounting for 38.63% of the onset season: spring was the main part of the disease. (8) the positive rate of HP infection was 82.2in TCM syndrome, the main symptoms of 1: 1 were as follows: regurgitation 91C) and heart-burning 84.The main diseases were liver and stomach, spleen, heart, lung, gallbladder and so on, and there was certain correlation between liver and stomach, heart, lung, gallbladder and so on. 3 the distribution of the four syndrome types: deficiency, deficiency of qi, yang, phlegm, accumulation of food, dampness and heat, and blood stasis: the disease can be divided into five types: dampness and heat accumulation, phlegm and stasis internal obstruction, liver and stomach stagnation, and liver and stomach stagnation, respectively, which are classified into five types: internal dampness and heat accumulation syndrome, phlegm and stasis internal obstruction syndrome, liver and stomach stagnation heat syndrome, and so on. Type spleen and stomach deficiency cold syndrome, like liver and stomach disharmony syndrome. Conclusion the patients with NERD were mainly middle and young people; the incidence of female was higher than that of male; the incidence of disease was related to mood, infection of HP in season and so on, but there was no clear correlation with body weight, diet rule, sleep quality and so on. Heart burning is the main symptom; disease position: the main syndromes of this disease are related to the liver and stomach, spleen, heart, lung, gallbladder, etc.; the disease: there are deficiency, deficiency can see Qi deficiency, Yang deficiency; the positivist can see phlegm turbid, food accumulation, dampness and heat, etc. Blood stasis; Syndrome distribution: the disease can be divided into five types: dampness and heat accumulation syndrome, phlegm and blood stasis syndrome, liver and stomach stagnation syndrome, spleen and stomach deficiency cold syndrome, liver and stomach disharmony syndrome.
【学位授予单位】：北京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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