清肝燥湿解毒汤治疗慢性乙型病毒性肝炎肝郁脾虚兼湿热型的临床观察

发布时间：2018-06-17 11:43

本文选题：清肝燥湿解毒汤 + 慢性乙型病毒性肝炎　；参考：《黑龙江中医药大学》2016年硕士论文

【摘要】：目的：观察清肝燥湿解毒汤对慢性乙型病毒性肝炎(肝郁脾虚兼湿热型)患者DNA的影响以及患者临床症状、体征变化,探讨中药对慢性乙型病毒性肝炎的疗效。方法：此次收入的患者均来源于2015年3月24日-2016年1月黑龙江中医药大学附属第一医院肝脾胃病科门诊收治的患者,共纳入45例。所有患者均经西医诊断标准诊断为慢性乙型病毒性肝炎,经中医辨证为肝郁脾虚兼湿热型。年龄在18-45岁之间,男女不限,入组前已诊为肝炎患者,且HBV-DNA含量测定在1.0E+04-1.0E+07之间。就诊前半年内未服用抗病毒药,且转氨酶持续升高,高于正常数值的2-3倍。连续服药3个月,每2周复诊1次,每个月复查一次DNA含量。治疗期间忌食辛辣、生冷、油腻等刺激性食物,禁饮咖啡、烟酒及浓茶,注意休息,并停服其他可能影响此次临床观察的任何药物。疗后经统计学处理比较患者治疗各阶段HBV-DNA含量变化,以及临床症候的改善情况。结果：1.治疗后各阶段,症状积分明显低于上一治疗阶段,且与治疗前一阶段比较有差异(P0.05)。2.治疗后各阶段,病毒含量明显低于上一治疗阶段,且与治疗前一阶段比较有差异(P0.05)。3.患者在治疗各阶段期间均无明显不良反应及毒副作用。治疗期间有5例患者因未完成临床观察,中途失联,故病例脱落。结论：1.清肝燥湿解毒汤可以抑制HBV复制,降低病毒的含量。2.清肝燥湿解毒汤可改善慢性乙型病毒性肝炎患者的临床症候。
[Abstract]:Objective: to observe the effect of Qinggan Dishishish-jiedu decoction on DNA of patients with chronic viral hepatitis B (liver stagnation and spleen deficiency combined with damp-heat type) and the changes of clinical symptoms and signs, and to explore the curative effect of traditional Chinese medicine on chronic viral hepatitis B. Methods: all the patients were from the outpatient department of liver, spleen and stomach of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine from March 24, 2015 to January, 2016. A total of 45 patients were included. All patients were diagnosed as chronic viral hepatitis B by western medicine, and liver stagnation and spleen deficiency combined with dampness and heat were diagnosed by traditional Chinese medicine. The patients aged between 18 and 45 years old, male and female, were diagnosed with hepatitis before admission, and the HBV-DNA content was determined between 1.0E04-1.0E07. No antiviral drugs were taken in the first half of the year, and transaminase increased continuously, 2-3 times higher than the normal value. Take medicine continuously for 3 months, visit once every 2 weeks, recheck DNA content once a month. Avoid spicy, cold, greasy and other irritant foods during the treatment. Do not drink coffee, alcohol, tobacco and strong tea, take rest and stop taking any other drugs that may affect the clinical observation. After treatment, the changes of HBV-DNA and the improvement of clinical symptoms were compared. The result is 1: 1. The symptom score of each stage after treatment was significantly lower than that of the previous stage, and there was a difference compared with the previous stage (P0.05. 2). The virus content in each stage after treatment was significantly lower than that in the previous treatment stage, and there was a difference compared with the previous stage (P0.05. 3). There were no significant adverse reactions and side effects in all stages of treatment. During the course of treatment, 5 patients lost their connection because they had not completed the clinical observation. Conclusion 1. Qinggan dry dampness jiedu decoction can inhibit HBV replication and reduce virus content. 2. Qinggan Dishish-jiedu decoction can improve the clinical symptoms of patients with chronic viral hepatitis B.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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