经前期综合征肝气郁证患者激活脑区定位分析

发布时间：2018-06-17 13:31

本文选题：功能性磁共振成像 + 经前期综合征　；参考：《中华中医药杂志》2017年05期

【摘要】：目的:明确经前期综合征(PMS)肝气郁证患者相关脑区定位。方法:受试者符合美国妇产科学会(ACOG)国际诊断标准、纳入标准;中医证候诊断符合PMS患者肝气郁证诊断标准。被试者在经前3-7d利用功能磁共振成像技术(fMRI)对相关脑区进行定位,在任务态,病例组和对照组在扫描过程中均观看中性和负性情绪诱发图片。将所得数据利用自带SPM8软件处理;结果:负性情绪图片任务下,PMS肝气郁证患者相对健康组激活增强的脑区:右侧小脑脚1区和右侧小脑6区、小脑前叶、小脑山顶、小脑结节等;激活减弱的脑区有右侧眶内额上回、右侧额中回、额叶内侧面(BA32)、右侧眶部额下回、眶额区(BA11)、额下回前下部皮层(BA47)、额极区(BA10)、额中、下回前部的上外额叶皮层(BA46)、额叶下部眶额皮层(BA25)等。结论:由此得出,病例组比对照组在小脑等脑区激活增强,在前额叶部位激活减弱。PMS肝气郁证主要调控脑区在额叶(尤其是眶额部皮质、额叶内侧面)、小脑相关脑区。
[Abstract]:Objective: to determine the location of related brain regions in PMS patients with liver qi depression. Methods: the subjects met the international diagnostic criteria of ACOG and the criteria of TCM syndromes in accordance with the criteria of liver qi depression in patients with PMS. Functional magnetic resonance imaging (fMRI) was used to localize the related brain regions in the first 3 to 7 days. The neutral and negative emotion-induced images were observed in the task state, the case group and the control group during the scanning. The data were processed with SPM8 software. Results: PMS patients with liver qi depression were activated and enhanced brain regions: right cerebellar foot area 1 and right cerebellar area 6, cerebellum anterior lobe, top of cerebellum, PMS patients with liver qi depression, right cerebellar foot area 1 and right cerebellum 6, cerebellum anterior lobe, top of cerebellum, Cerebellar nodules and so on; the areas with reduced activation include right superior orbital frontal gyrus, right middle frontal gyrus, right medial frontal gyrus, medial frontal lobe BA32, right orbital inferior frontal gyrus, orbital frontal area, anterior inferior cortex of inferior frontal gyrus, anterior cortex of inferior frontal gyrus, frontal polar area, BA10, middle frontal region, right orbital inferior frontal gyrus, right orbital subfrontal gyrus, anterior cortex of inferior frontal gyrus. The upper frontal cortex of the inferior gyrus is BA46, and the orbital frontal cortex of the lower frontal lobe is BA25. Conclusion: the activation of PMS in the prefrontal lobe is weaker than that in the control group. PMS mainly regulates the frontal cortex (especially the orbitofrontal cortex, the medial frontal lobe and the cerebellar related brain area).
【作者单位】：山东中医药大学;福建中医药大学;
【基金】：科技部十五攻关资助项目(No.2004BA721A04)~~
【分类号】：R271.11

【相似文献】