基于数据挖掘的防治慢性肺系疾病膏方用药规律研究

发布时间：2018-06-18 08:18

本文选题：膏方 + 肺系疾病　；参考：《山东中医药大学》2016年博士论文

【摘要】：目的:本论文旨在通过对防治肺系疾病膏方历代文献的整理研究,统计分析防治肺系疾病膏方的发展状况、组方特点以及用药情况,探讨膏方的组方原则,以期指导防治慢性肺系疾病膏方的选药及组方应用,为慢性肺系疾病的膏方治疗提供用药指导。方法:运用频数统计和聚类分析等现代数据挖掘方法,对防治肺系疾病80年代中期前后膏方组成药物进行用药频数、药性、药味、功效的统计分析,以及统计治疗病证,进一步对优势病种支气管哮喘、慢性阻塞性肺病以及慢性咳嗽进行高频药物的聚类分析。结果:(1)80年代中期前膏方组成药物以苦味药为主,寒热性区别不大,主功效以止咳化痰平喘药为主;80年代中期后膏方以甘味药为主,温性药最多,主功效以补虚药最多;归经以入肺脾肾三经为主;(2)80年代中期后膏方治疗的优势病种居前三位的是支气管哮喘、慢性阻塞性肺病和慢性咳嗽;(3)防治支气管哮喘的膏方药物使用以补气药居首,化痰祛瘀居次,并少佐行气消食药;防治慢性阻塞性肺病膏方以补益肺脾肾三脏治本,化痰祛瘀治标为特点;防治慢性咳嗽膏方药物以止咳化痰治标为主,同时辅以益气、补益肺脾。结论:从数据挖掘以及量化的研究方式探讨防治慢性肺系疾病的膏方药物使用规律及组方原则是客观、切实可行的,为进一步指导膏方的合理遣方用药提供了依据,为进一步研究膏方的临床疗效奠定基础。
[Abstract]:Objective: the purpose of this paper is to analyze the development, characteristics and medication of the recipe for prevention and treatment of pulmonary diseases by analyzing the literature of the prevention and treatment of lung diseases ointment in the past dynasties, and to explore the principle of the prescription. In order to guide the prevention and treatment of chronic pulmonary diseases prescription selection and prescription application, for chronic lung disease ointment treatment to provide medication guidance. Methods: using modern data mining methods, such as frequency statistics and cluster analysis, to analyze the frequency, medicinal properties, taste and efficacy of the ointment before and after the mid-1980s for the prevention and treatment of pulmonary diseases, as well as statistical treatment of disease and syndromes. Cluster analysis of high-frequency drugs for bronchial asthma, chronic obstructive pulmonary disease and chronic cough was carried out. Results before the mid-1980s, the components of the ointment prescriptions were mainly bitter herbs, but the difference between cold and heat was not significant. The main efficacy was to relieve cough and reduce phlegm and relieve asthma. After the mid-1980s, the main effect of the cream prescription was mainly sweet flavor, the most warm and the main effect was the tonifying and deficiency medicine. The leading diseases in the treatment of bronchial asthma in the mid-1980s were bronchial asthma, chronic obstructive pulmonary disease and chronic cough. Resolving phlegm and removing blood stasis is the second place, and less accompanied by Qi and eliminating food. The prescription for prevention and treatment of chronic obstructive pulmonary disease is characterized by tonifying the root causes of the three viscera of lung, spleen and kidney, removing phlegm and removing blood stasis, and preventing and treating chronic cough ointment mainly by relieving cough and resolving phlegm and treating symptoms, and at the same time supplementing qi, Tonify the lung and spleen. Conclusion: it is objective and feasible to explore the rule and principle of prescriptions for the prevention and treatment of chronic pulmonary diseases from data mining and quantitative research methods, which provides the basis for further guiding the rational prescription of ointment. To lay a foundation for further study of the clinical efficacy of ointment.
【学位授予单位】：山东中医药大学
【学位级别】：博士
【学位授予年份】：2016
【分类号】：R259

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