白虎加人参汤对2型糖尿病患者氧化应激水平与胰岛素敏感性的影响

发布时间：2018-06-18 22:27

本文选题：白虎加人参汤 + 型糖尿病　；参考：《中药药理与临床》2017年05期

【摘要】：目的:探讨白虎加人参对2型糖尿病患者氧化应激水平与胰岛素敏感性的影响。方法:以我院收治的120例2型糖尿病患者为研究对象,采用随机数字表分为对照组与观察组两组(各60例),均给予口服降糖药二甲双胍,必要时给予胰岛素注射联合治疗,并予以降脂药辛伐他汀等对症治疗,观察组在对照组治疗基础上加用白虎加人参汤治疗,两组均治疗8周,疗程结束后比较两组氧化应激水平,包括超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)及8-异前列腺素(8-iso-PGF2ɑ)水平,并计算胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)及胰岛素敏感指数(HOMA-ISI),检测治疗前后两组脂糖代谢情况,包括空腹血糖(FPG)、餐后2h血糖(2h PG)、血清总胆固醇(TC)、甘油三脂(TG)水平,并检测炎性因子白介素-6(IL-6)、肿瘤坏死因子-ɑ(TNF-ɑ)及血管内皮功能指标内皮素-1(ET-1)及一氧化氮(NO)。结果:治疗后对照组中医症候总积分(4.83±0.37)分,观察组(3.35±0.29)分,两组评分较治疗前显著下降,但观察组下降幅度明显高于对照组;治疗后两组氧化应激指标MDA、8-iso-PGF2ɑ及HOMA-IR较治疗前明显下降,SOD、GSH-Px及HOMA-β、HOMA-ISI明显上升,且观察组波动幅度均明显高于对照组;两组脂糖代谢指标FPG、2h PG、TC、TG及炎性因子IL-6、TNF-ɑ,血管内皮功能ET-1较治疗前明显下降,NO明显上升,且组间差异均显著。结论:白虎加人参汤可有效改善2型糖尿病患者氧化应激反应,同时抑制胰岛素抵抗现象,加强胰岛素敏感性,加强疗效。
[Abstract]:Objective: to investigate the effect of Baihu plus ginseng on oxidative stress and insulin sensitivity in type 2 diabetes mellitus. Methods: 120 patients with type 2 diabetes mellitus in our hospital were randomly divided into two groups: the control group and the observation group (60 cases in each group) were treated with oral metformin and insulin injection when necessary. The observation group was treated with Baihu plus Renshen decoction on the basis of the treatment of the control group. The two groups were treated for 8 weeks. The levels of oxidative stress in the two groups were compared after the end of the course of treatment. Including the levels of superoxide dismutase (SOD), malondialdehyde (MDAA), glutathione peroxidase (GSH-Px) and 8-iso-PGF2 (8-iso-PGF2), The insulin resistance index (HOMA-IRN), insulin secretion index (HOMA- 尾) and insulin sensitivity index (HOMA-ISI) were calculated. The lipid and glucose metabolism of the two groups were measured before and after treatment, including fasting blood glucose, 2 h postprandial glucose, serum total cholesterol (TCN), triglyceride (TG). The inflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor (TNF-1), endothelin 1 (et 1) and nitric oxide (no) were detected. Results: the total score of TCM symptom was 4.83 卤0.37 in the control group and 3.35 卤0.29 in the observation group. The score of the two groups was significantly lower than that before treatment, but the decrease of the observation group was significantly higher than that of the control group. After treatment, the oxidative stress indexes MDA8-iso-PGF2 and HOMA-IR decreased significantly, and the GSH-Px and HOMA- 尾 -HOMA-ISI of the two groups increased significantly, and the fluctuation range of the observation group was significantly higher than that of the control group. The lipid glucose metabolism index FPG 2 h PGN TCU TG, the inflammatory factor IL-6 TNF- 1 and the endothelium function ET-1 of the two groups decreased significantly compared with those before treatment, and the difference between the two groups was significant. Conclusion: Baihu plus Renshen decoction can effectively improve oxidative stress response, inhibit insulin resistance, enhance insulin sensitivity and enhance curative effect in type 2 diabetic patients.
【作者单位】：武汉市普爱医院;
【基金】：武汉市卫生局项目WX-12C25
【分类号】：R259

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