冠心止痛胶囊对稳定性心绞痛患者血管内皮功能及炎症反应的影响

发布时间：2018-06-19 01:18

本文选题：冠心止痛胶囊 + 稳定性心绞痛　；参考：《河南中医药大学》2016年硕士论文

【摘要】：目的：本研究通过观察冠心止痛胶囊对冠心病稳定性心绞痛患者的中医证候疗效、心绞痛疗效、肱动脉血流介导的舒张功能(FMD)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)的影响,以了解冠心止痛胶囊的作用机理,评价该方对冠心病稳定性心绞痛患者的血管内皮功能的改善及炎症反应的减轻作用。方法：选择河南省中医药研究院附属医院门诊符合纳入标准的冠心病稳定性心绞痛的患者60例,中医诊断为胸痹(痰瘀交阻证),按1：1的比例随机分为治疗组与对照组,各30例,两组均给以基础治疗予阿司匹林肠溶片100mg,每晚一次,口服；酒石酸美托洛尔12.5mg,早晚各一次,口服；阿托伐他汀钙片10mg,每晚一次,口服。治疗组加用冠心止痛胶囊(河南省中医药研究院附属医院院内制剂),4粒,每日3次,口服,3个月为一疗程,观察一个疗程,观察比较该方治疗前后中医证候、心绞痛分级和肱动脉血流介导的舒张功能、C-反应蛋白、肿瘤坏死因子-α的变化情况。结果：(1)中医证候疗效：治疗组中医证候的疗效总有效率为93.33%,对照组总有效率为66.67%,两组比较,差异有统计学意义(P0.05)。(2)两组心绞痛分级改善情况：治疗组心绞痛的改善总有效率为83.33%,对照组总有效率为46.67%,两组比较,差异有统计学意义(P0.05)。(3)两组FMD、CRP、TNF-α的变化情况：两组治疗后与治疗前相比,均能升高FMD,降低患者的血清CRP、TNF-α,治疗组的改善明显优于对照组,有统计学意义(P0.05)。结论：本研究显示：冠心止痛胶囊能有效的改善稳定性心绞痛患者中医临床证候,改善心绞痛分级,其临床疗效机制可能与血管内皮功能的改善和炎症反应的减轻有关。
[Abstract]:Objective: to observe the effects of Guanxin Zhitong capsule on TCM syndromes, angina pectoris, blood flow mediated diastolic function of brachial artery (FMD-CRPN) and tumor necrosis factor- 伪 (TNF- 伪) in patients with stable angina pectoris of coronary heart disease. To understand the mechanism of Guanxin Zhitong capsule and evaluate the effect of Guanxin Zhitong capsule on the improvement of vascular endothelial function and inflammation in patients with stable angina pectoris of coronary heart disease. Methods: sixty patients with stable angina pectoris of coronary heart disease were selected from outpatient clinic of affiliated Hospital of Henan Institute of traditional Chinese Medicine. The patients were diagnosed as chest obstruction (phlegm and blood stasis syndrome) and randomly divided into treatment group and control group according to the proportion of 1:1. 30 patients in each group were given basic treatment with 100 mg aspirin enteric-coated tablets once a night; metoprolol tartrate 12.5 mg in the morning and evening; Atto vastatin calcium tablet 10 mg once a night. The treatment group was treated with Guanxin Zhitong capsule (4 capsules of Guanxin Zhitong capsule, 3 times a day, 3 months as a course of treatment), observing a course of treatment, observing and comparing the TCM syndromes before and after the treatment. Changes of angina pectoris grade and brachial artery blood flow mediated diastolic function of C-reactive protein and tumor necrosis factor-伪. Results: the total effective rate of TCM syndromes in the treatment group was 93.33 and that in the control group was 66.67. The improvement of angina pectoris grade in the treatment group was 83.33 and the total effective rate in the control group was 46.67. There was significant difference between the two groups (P 0.05, P < 0.05). The changes of TNF- 伪 in the two groups were as follows: compared with before treatment, the two groups could increase FMDand decrease the serum level of CRP- TNF- 伪. The improvement of the treatment group was obviously better than that of the control group, and there was significant difference between the treatment group and the control group (P 0.05). Conclusion: Guanxin Zhitong capsule can effectively improve TCM syndromes and angina pectoris grading in patients with stable angina pectoris. The mechanism of clinical curative effect may be related to the improvement of vascular endothelial function and the reduction of inflammatory reaction.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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